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Evidence found and GRADE certainty

2,805 questions · 2,912 findings · 307 reviews · Headline outcomes only

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No studies found 706 · 24.2%GRADE not reported 133 · 4.6%Very low 786 · 27%Low 696 · 23.9%Moderate 474 · 16.3%High 117 · 4%

Nutrition systems strengthening interventions targeting children vs no intervention or standard care to reduce stunting (height‐for‐age, length at 18 months)

Length (cm) · children under 5 years old

Nutrition systems strengthening interventions targeting children may leads to higher length (cm) at 18 months compared with no intervention or standard care to reduce stunting (height‐for‐age,… (low certainty).

1 finding from 1 review

Micronutrient or macronutrient supplementation interventions in children vs no intervention, or placebo to reduce stunting (height‐for‐age, length velocity, and length at 12 months)

Length velocity (change in cm since start of supplementation) · children under 5 years old
1 finding from 1 review

Micronutrient or macronutrient supplementation interventions in children vs no intervention, or placebo to reduce stunting (height‐for‐age, length velocity, and length at 12 months)

Length velocity (cm/month) · children under 5 years old

It is very uncertain whether micronutrient or macronutrient supplementation interventions in… changes length velocity (cm/month) compared with no intervention, or placebo to reduce stunting (height‐for‐age,… (very low certainty).

1 finding from 1 review

Micronutrient or macronutrient supplementation interventions in children vs no intervention, or placebo to reduce stunting (height‐for‐age, length velocity, and length at 12 months)

Length (cm) · children under 5 years old

Micronutrient or macronutrient supplementation interventions in… showed no clear difference in length (cm) at 12 months compared with no intervention, or placebo to reduce stunting (height‐for‐age,… (low certainty).

1 finding from 1 review

Omega‐3 fatty acids and antioxidants vs standard diet or placebo

Mortality within the longest · adults (aged 18 years or older), mechanically ventilated participants with ARDS as defined by the Berlin definition of ARDS or, for older…

Omega‐3 fatty acids and antioxidants showed no clear difference in all‐cause mortality (longest period reported) compared with placebo or standard nutrition (low certainty).

1 finding from 1 review

Omega‐3 fatty acids and antioxidants vs standard diet or placebo

Adverse effects (cardiac) · adults (aged 18 years or older), mechanically ventilated participants with ARDS as defined by the Berlin definition of ARDS or, for older…

It is very uncertain whether omega‐3 fatty acids and antioxidants changes cardiac adverse events (study author reported anytime during study… compared with placebo or standard nutrition (very low certainty).

1 finding from 1 review

Omega‐3 fatty acids and antioxidants vs standard diet or placebo

Gastrointestinal adverse events · adults (aged 18 years or older), mechanically ventilated participants with ARDS as defined by the Berlin definition of ARDS or, for older…

It is very uncertain whether omega‐3 fatty acids and antioxidants changes gastrointestinal adverse events (study author reported anytime… compared with placebo or standard nutrition (very low certainty).

1 finding from 1 review

Omega‐3 fatty acids and antioxidants vs standard diet or placebo

Study author‐reported adverse events · adults (aged 18 years or older), mechanically ventilated participants with ARDS as defined by the Berlin definition of ARDS or, for older…

It is very uncertain whether omega‐3 fatty acids and antioxidants changes total number of adverse events (study author reported anytime during… compared with placebo or standard nutrition (very low certainty).

1 finding from 1 review

Loratadine 10 mg vs placebo (4‐week intervention)

Primary outcome 2. Proportion of participants reporting adverse effects and serious adverse events throughout the study period · adults with eczema

Loratadine 10 mg/d showed no clear difference in primary outcome 2. Proportion of participants reporting adverse… compared with placebo (4‐week intervention) (low certainty).

1 finding from 1 review

Summary of findings: cycled vs culture‐based antibiotic therapy

Time to next isolation of PA · children (aged 1 to 12 years) with CF and a newly isolated PA infection

Summary of findings: cycled probably leads to higher time to next isolation of PA compared with culture‐based antibiotic therapy (moderate certainty).

1 finding from 1 review