Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,587 questions · 5,761 findings · 495 reviews

No studies found 1,011 · 17.5%GRADE not reported 1,797 · 31.2%Very low 1,100 · 19.1%Low 1,052 · 18.3%Moderate 649 · 11.3%High 152 · 2.6%

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Intervention not reported

Exacerbations requiring oral corticosteroids 7.3‐month · people with asthma

The intervention showed no clear difference in exacerbations requiring oral corticosteroids 7.3‐month (low certainty).

1 finding from 1 review

Intervention not reported

Exacerbations requiring oral corticosteroids3 months · adults or children with asthma

The intervention showed no clear difference in exacerbations requiring oral corticosteroids3 months (low certainty).

1 finding from 1 review

Intervention not reported

Oral contraceptive use during last sex (17 months) · middle or high school students with need for contraceptive information

The intervention probably leads to lower oral contraceptive use during last sex (17 months) (moderate certainty).

1 finding from 1 review

Selective or stepwise carious tissue removal vs Non-selective or complete carious tissue removal

Temporal change in the proportion of dentists utilizing SE/SW · Dentists managing deep carious lesions in permanent vital teeth

The proportion of dentists choosing selective or stepwise removal rose significantly over time, by about 1.6% per calendar year (meta-regression, p<0.05), a trend the authors described as borderline (ungraded).

1 finding from 1 review

Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Mucosal irritation / oral soft tissue allergic reaction (signs of sensitivity) · Children and adolescents aged 16 years or less

The review found no eligible studies for this question.

1 finding from 1 review

Pilocarpine vs placebo

Other oral symptoms (oral discomfort, dysphonia) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review

Local and systemic reactions after administration of Tetanus Diphtheria acelluar Pertussis vaccine vs saline placebo

Systemic reactions ‐ fever (oral temperature ≥ 38°C) · patients with local and systemic reactions

Local and systemic reactions after administration of Tetanus… showed no clear difference in systemic reactions ‐ fever (oral temperature ≥ 38°C) compared with saline placebo (moderate certainty).

1 finding from 1 review

Maintenance LTRA vs placebo

Number of participants experiencing one or more episode requiring treatment with oral steroids · episodic viral wheeze in children

Maintenance LTRA showed no clear difference in number of participants experiencing one or more episode requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Intermittent LTRA vs placebo

Number of participants experiencing one or more episode requiring treatment with oral steroids · episodic viral wheeze in children

Intermittent LTRA showed no clear difference in number of participants experiencing one or more episode requiring… compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Live birth or ongoing pregnancy IM vs oral · subfertile women

It is very uncertain whether the intervention changes live birth or ongoing pregnancy IM vs oral (very low certainty).

1 finding from 1 review

Intervention not reported

Live birth or ongoing pregnancy Vaginal/rectal vs oral · subfertile women

The intervention showed no clear difference in live birth or ongoing pregnancy Vaginal/rectal vs oral (low certainty).

1 finding from 1 review

Intervention not reported

OHSS IM vs oral · subfertile women

It is very uncertain whether the intervention changes OHSS IM vs oral (very low certainty).

1 finding from 1 review