Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth)
1.23% APF gel + oral health education was probably more effective than Oral health education for arrest or reversal of facial/lingual carious lesions (RR 2.47, 95% CI 1.95 to 3.13; moderate certainty).
1 finding from 1 review
Intervention not reported
Marginal restoration discoloration (adverse event)
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Pain · Children with carious vital pulp exposure in primary incisors
No statistically significant difference in pain between pulpotomy and pulpectomy (RR 2.06, 95% CI 0.31 to 13.8; ungraded).
1 finding from 1 review
RR 2.06 [0.31, 13.8]
Studies not reported
GRADE not reported
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
0.2% NaF mouthrinse + supervised toothbrushing was probably less effective than Resin infiltration + 5% NaF varnish for arrest or reversal of occlusal carious lesions (RR 0.61, 95% CI 0.43 to 0.85; moderate certainty).
1 finding from 1 review
DMFT/DMFS index (dental caries experience) · Children aged 0-12 years (studies published before 2015)
In studies published before 2015, OHPPs were associated with lower DMFT (OR 0.01, 95% CI 0.00 to 0.13; ungraded).
1 finding from 1 review
Pulp canal obliteration · Children with carious vital pulp exposure in primary incisors
Pulp canal obliteration was reported narratively (mainly in the pulpotomy group) and was not pooled.
1 finding from 1 review
Intervention not reported
Clinical and radiographic success
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Oral health-related quality of life · Children and adolescents with juvenile idiopathic arthritis (JIA)
Evidence on OHRQoL was limited: one study found no significant difference between groups while another found orofacial symptoms affected daily life more in JIA; no pooled estimate (ungraded).
1 finding from 1 review
Santos et al. [29] found oral health status had little or no effect on well-being with no significant difference between JIA and healthy groups (SF:13-B-PCPQ); Leksell et al. [38] found orofacial symptoms influenced…
2 studies · 111 participants
GRADE not reported
Arrest or reversal of noncavitated carious lesions on any coronal surface · Children and adults with noncavitated carious lesions on any coronal surface (primary and permanent teeth)
10% CPP-ACP paste was probably less effective than 5% NaF varnish for arrest or reversal of any-coronal carious lesions (RR 0.48, 95% CI 0.38 to 0.6; moderate certainty).
1 finding from 1 review
Plaque index (PI) / oral hygiene · Children and adolescents with juvenile idiopathic arthritis (JIA)
Evidence on oral hygiene/dental plaque was inconsistent: several studies found higher plaque in the JIA group while others found no difference; no pooled estimate (ungraded).
1 finding from 1 review
Some studies showed a statistically higher Plaque Index or Simplified Oral Hygiene Index (OHI-S) in the JIA group [23, 25, 28, 31]; other studies did not find this association [22, 26, 27, 29, 30, 39]. Meta-analysis…
Studies not reported
GRADE not reported
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
Caries prevalence was lower in those with mean age >10 years at 57% (95% CI 0.45 to 0.68); certainty not graded.
1 finding from 1 review
Arrest or reversal of noncavitated facial/lingual carious lesions · Children and adults with noncavitated carious lesions on facial/lingual surfaces (primary and permanent teeth)
5% NaF varnish may be more effective than no treatment for arrest or reversal of facial/lingual carious lesions (RR 2.3, 95% CI 1.58 to 3.34; low certainty).
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
5% NaF varnish was probably more effective than no treatment for arrest or reversal of occlusal carious lesions (RR 1.97, 95% CI 1.63 to 2.4; moderate certainty).
1 finding from 1 review
Arrest or reversal of noncavitated occlusal carious lesions · Children and adults with noncavitated carious lesions on occlusal surfaces (primary and permanent teeth)
0.2% NaF mouthrinse + supervised toothbrushing was probably more effective than no treatment for arrest or reversal of occlusal carious lesions (RR 1.94, 95% CI 1.54 to 2.46; moderate certainty).
1 finding from 1 review
Intervention not reported
Dental caries prevalence · Children (<12 years) and adolescents (12-18 years) with type 1 diabetes
Caries prevalence was higher in those with mean age <=10 years at 80% (95% CI 0.74 to 0.85); certainty not graded.
1 finding from 1 review
Arrest or reversal of noncavitated carious lesions on any coronal surface · Children and adults with noncavitated carious lesions on any coronal surface (primary and permanent teeth)
5% NaF varnish was probably more effective than no treatment for arrest or reversal of any-coronal carious lesions (RR 2.15, 95% CI 1.8 to 2.57; moderate certainty).
1 finding from 1 review
Periodontal conditions (gingival inflammation, bleeding on probing, probing depth, clinical attachment loss) · Children and adolescents with juvenile idiopathic arthritis (JIA)
Periodontal conditions (gingival inflammation, bleeding, probing depth, attachment loss) were more frequently reported in children/adolescents with JIA than in healthy peers, although not all studies agreed; no pooled estimate (ungraded).
1 finding from 1 review
Many studies documented poorer periodontal status among children/adolescents with JIA: more gingival inflammation and bleeding [22, 29, 31], bleeding on probing [25], deeper probing depth [25, 26] and periodontal…
Studies not reported
GRADE not reported
Dental anxiety (subjective and objective scores) · Children (ages 6-12) receiving pit-and-fissure sealants
Er:YAG laser preparation added to acid-etching did not increase children's dental anxiety versus acid-etching alone (P > 0.05; ungraded, single study).
1 finding from 1 review
Shindova 2018 (Er:YAG laser+acid vs acid-etching): no significant difference between initial and final subjective anxiety scores for the two groups; use of the Er:YAG laser did not provoke anxiety (P > 0.05).
1 study · 64 participants
GRADE not reported
Quantitative light-induced fluorescence (QLF), fluorescence loss · Patients (mainly children) with white spot lesions (WSL)
CPP-ACP toothpaste did not differ significantly from placebo paste (fluoride control) for white spot lesion remineralization on QLF (MD 0.08, 95% CI -0.91 to 1.08; ungraded).
1 finding from 1 review
Arrest or reversal of noncavitated and cavitated root carious lesions · Adults (including institutionalized/older adults) with noncavitated and cavitated carious lesions on root surfaces (permanent teeth)
38% SDF + potassium iodide solution (applied annually) may not differ from 5% NaF varnish for arrest or reversal of root carious lesions (RR 0.8, 95% CI 0.05 to 11.95; very low certainty).
1 finding from 1 review