All‐cause mortality · women with operable primary breast cancer
Radiotherapy alone showed no clear difference in all‐cause mortality compared with full axillary surgery (high certainty).
1 finding from 1 review
Local recurrence · women with operable primary breast cancer
Radiotherapy alone leads to lower local recurrence compared with full axillary surgery (high certainty).
1 finding from 1 review
Overall survival · high‐grade glioma
Daily conventionally fractionated radiotherapy probably leads to higher overall survival compared with no radiotherapy (supportive care alone) (moderate certainty).
1 finding from 1 review
Adverse effects · high‐grade glioma
1 finding from 1 review
Progression‐free survival · high‐grade glioma
1 finding from 1 review
Quality of life · high‐grade glioma
1 finding from 1 review
Reduction in analgesic and narcotic use One month after radiation · adults with metastatic extradural spinal cord compression (poor prognosis, no spinal instability or bony impingement of cord)
Split‐course radiotherapy (8 fractions, 30 Gy) showed no clear difference in reduction in analgesic and narcotic use One month after radiation compared with short‐course radiotherapy (2 fractions, 16 Gy) (moderate certainty).
1 finding from 1 review
Urinary continence One month after radiation · adults with metastatic extradural spinal cord compression (poor prognosis, no spinal instability or bony impingement of cord)
Split‐course radiotherapy (8 fractions, 30 Gy) showed no clear difference in urinary continence One month after radiation compared with short‐course radiotherapy (2 fractions, 16 Gy) (moderate certainty).
1 finding from 1 review
Local recurrence · adults with metastatic extradural spinal cord compression (poor prognosis, no spinal instability or bony impingement of cord)
Split‐course radiotherapy (8 fractions, 30 Gy) showed no clear difference in local recurrence compared with short‐course radiotherapy (2 fractions, 16 Gy) (low certainty).
1 finding from 1 review
Adverse events Grade 3 oesophagitis, diarrhoea and nausea · adults with metastatic extradural spinal cord compression (poor prognosis, no spinal instability or bony impingement of cord)
Split‐course radiotherapy (8 fractions, 30 Gy) showed no clear difference in adverse events Grade 3 oesophagitis, diarrhoea, and nausea compared with short‐course radiotherapy (2 fractions, 16 Gy) (moderate certainty).
1 finding from 1 review
Quality of life · adults with metastatic extradural spinal cord compression (poor prognosis, no spinal instability or bony impingement of cord)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Ambulation · adults with metastatic extradural spinal cord compression (poor prognosis, no spinal instability or bony impingement of cord)
Split‐course radiotherapy (8 fractions, 30 Gy) showed no clear difference in ambulation One month after treatment compared with short‐course radiotherapy (2 fractions, 16 Gy) (moderate certainty).
1 finding from 1 review
Survival · adults with metastatic extradural spinal cord compression (poor prognosis, no spinal instability or bony impingement of cord)
1 finding from 1 review
The incidence and severity of chemotherapy‐ or radiotherapy‐related toxicities · Patients with cancer receiving chemotherapy and/or radiotherapy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Overall survival, post-surgery chemotherapy vs surgery alone (no radiotherapy) · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
Surgery +/- radiotherapy + (adjuvant) chemotherapy showed no clear difference in overall survival, adjuvant chemotherapy vs observation alone… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy… (moderate certainty).
1 finding from 1 review
Elevated alanine aminotransferase · participants with unresectable hepatocellular carcinoma
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Elevated total bilirubin · participants with unresectable hepatocellular carcinoma
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
All‐cause mortality (at 1 year) · participants with unresectable hepatocellular carcinoma
It is very uncertain whether external beam radiotherapy (EBRT) changes all‐cause mortality (at 1 year) compared with transarterial chemoembolisation (TACE) (very low certainty).
1 finding from 1 review
Serious adverse events · participants with unresectable hepatocellular carcinoma
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Complete response plus partial response Length of · participants with unresectable hepatocellular carcinoma
1 finding from 1 review