What do systematic reviews say?

Pregabalin vs placebo

• Pregabalin for pain in fibromyalgia in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1874 participants
  High

Pregabalin vs placebo

• Antiepileptic drugs for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 107 participants
  Very low

SSRIs or SNRIs vs other antidepressants

SSRIs or SNRIs showed no clear difference in withdrawals due to adverse events compared with other antidepressants (low certainty).

• Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
  OR 1.04 [0.41, 2.6]
  4 studies · 257 participants
  Low

Amitriptyline vs placebo

• Antidepressants for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 123 participants
  Very low

Citalopram vs placebo

• Antidepressants for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 115 participants
  Very low

Amitriptyline vs gabapentin

• Antidepressants for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 34 participants
  Very low

SSRIs or SNRIs vs placebo

It is very uncertain whether SSRIs or SNRIs changes withdrawals due to adverse events compared with placebo (very low certainty).

• Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
  OR 3.72 [0.79, 17.53]
  3 studies · 190 participants
  Very low