Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

36 questions · 36 findings · 29 reviews · Musculoskeletal

No studies found 4 · 11.1%GRADE not reported 3 · 8.3%Very low 2 · 5.6%Low 11 · 30.6%Moderate 10 · 27.8%High 6 · 16.7%

Certolizumab pegol 200 mg sc (with or without MTX) vs placebo (with or without MTX)

Withdrawals due to adverse events · patients with rheumatoid arthritis in adults

Certolizumab pegol 200 mg sc (with or without MTX) leads to higher withdrawals due to adverse events All doses of certolizumab pegol… compared with placebo (with or without MTX) (high certainty).

1 finding from 1 review

Paracetamol vs placebo

Withdrawals due to adverse events · Patients with osteoarthritis of the knee or hip

Paracetamol showed no clear difference in withdrawals due to adverse events 24 weeks compared with placebo (moderate certainty).

1 finding from 1 review

Diacerein vs placebo

Withdrawals due to adverse events · patients with osteoarthritis

Diacerein showed no clear difference in withdrawal due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Allopurinol vs placebo

Withdrawals due to adverse events · people with chronic gout

Allopurinol showed no clear difference in withdrawal due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Intermittent/cyclic etidronate 400 mg/day vs placebo

Withdrawals due to adverse events · postmenopausal women with a higher risk for fracturesa

It is very uncertain whether intermittent/cyclic etidronate 400 mg/day changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review

Belimumab 10 mg/kg vs placebo

Withdrawals due to adverse events · people with active systemic lupus erythematosus (but not active nephritis or active central nervous system involvement)

Belimumab 10 mg/kg showed no clear difference in withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Chondroitin vs placebo

Withdrawals due to adverse events · patients with osteoarthritis

Chondroitin showed no clear difference in withdrawals due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review