Findings

What do systematic reviews say?

6 questions · 6 findings · 4 reviews · Musculoskeletal

No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 66.7%Moderate 1 · 16.7%High 0 · 0%

Withdrawals due to adverse events · people with chronic gout

Allopurinol showed no clear difference in withdrawal due to adverse events compared with benzbromarone (low certainty).

1 finding from 1 review

Allopurinol for chronic gout 2014 · Cochrane Headline outcomes only
RR 0.8 [0.18, 3.58]
2 studies · 91 participants
Low

Withdrawals due to adverse events · people with chronic gout

Allopurinol showed no clear difference in withdrawal due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Allopurinol for chronic gout 2014 · Cochrane Headline outcomes only
RR 1.36 [0.61, 3.08]
2 studies · 453 participants
Moderate

Withdrawals due to adverse events · people with chronic gout

Benzbromarone showed no clear difference in withdrawal due to adverse events compared with allopurinol (low certainty).

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
RR 1.25 [0.28, 5.62]
2 studies · 91 participants
Low

Withdrawals due to adverse events · participants with chronic gout and sUA level > 0.36mmol/L

1 finding from 1 review

Dietary supplements for chronic gout 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Low

Withdrawals due to adverse events ‐ not reported · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Uricosuric medications for chronic gout 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Withdrawal due to adverse events Methotrexate discontinuation · patients with inflammatory arthritis on methotrexate

1 finding from 1 review