SAEs · people who smoke
Varenicline probably leads to higher SAEs (varenicline vs placebo or no medication) compared with placebo or no medication (moderate certainty).
1 finding from 1 review
Cardiac SAEs · people who smoke
Varenicline showed no clear difference in cardiac SAEs (varenicline vs placebo or no medication) compared with placebo or no medication (low certainty).
1 finding from 1 review
Neuropsychiatric SAEs · people who smoke
Varenicline showed no clear difference in neuropsychiatric SAEs (varenicline vs placebo or no medication) compared with placebo or no medication (low certainty).
1 finding from 1 review
Intervention not reported
Varenicline · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…
The intervention showed no clear difference in varenicline (low certainty).
1 finding from 1 review
Intervention not reported
Varenicline · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…
The intervention leads to higher varenicline (high certainty).
1 finding from 1 review
Intervention not reported
Cessation: Varenicline vs placebo · Smokers who cannot or do not want to quit smoking
The intervention showed no clear difference in cessation: Varenicline vs placebo (low certainty).
1 finding from 1 review
Intervention not reported
Varenicline versus placebo Smoking cessation · people who have quit smoking using a cessation intervention
The intervention probably leads to higher varenicline versus placebo Smoking cessation (moderate certainty).
1 finding from 1 review
Subgroup: varenicline only; smoking cessation (≥ 6 month · people who smoke
Reduction and pharmacotherapy probably leads to higher subgroup: varenicline only; smoking cessation (≥ 6 month compared with reduction alone (moderate certainty).
1 finding from 1 review
Intervention not reported
Varenicline plus behavioral intervention vs placebo plus behavioral intervention ‐ (repeated point prevalence abstinence (not even a puff/chew/session in the last 7 days) at each of weeks 5, 12, and 25 (combined), verified by CO cutoff < 10 ppm) · people who use waterpipe
The intervention showed no clear difference in varenicline plus behavioral intervention vs placebo plus behavioral… (low certainty).
1 finding from 1 review