What do systematic reviews say?

Quinolone vs aminoglycosides

• Topical antibiotics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 352 participants
  Very low

Topical quinolone vs quinolones

• Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 265 participants
  Very low

Topical quinolone vs intramuscular gentamicin

• Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 60 participants
  Very low

Topical quinolone vs oral amoxicillin‐clavulanic acid combination

• Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 56 participants
  Very low

Topical quinolone vs povidone‐iodine

It is very uncertain whether topical antibiotics (quinolones) changes suspected ototoxicity compared with povidone‐iodine (very low certainty).

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 40 participants
  Very low

Topical quinolone vs boric acid

The review found no eligible studies for this question.

• Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Systemic antifungal vs placebo/no treatment

Systemic antifungal showed no clear difference in adverse effects ‐ hepatic toxicity compared with placebo/no treatment (low certainty).

• Topical and systemic antifungal therapy for chronic rhinosinusitis 2018 · Cochrane Headline outcomes only
  RR 3.35 [0.14, 78.6]
  Studies not reported
  Low