Quinolone vs aminoglycosides
Suspected ototoxicity · people (of any age) with CSOM
1 finding from 1 review
- no estimate extracted2 studies · 352 participantsVery low
Findings
What do systematic reviews say?
28 questions · 28 findings · 13 reviews
No studies found 5 · 17.9%GRADE not reported 0 · 0%Very low 15 · 53.6%Low 5 · 17.9%Moderate 2 · 7.1%High 1 · 3.6%
Irinotecan vs non‐irinotecan‐containing regimens
Treatment discontinuation due to toxicity · people with advanced gastric cancer
It is very uncertain whether irinotecan changes treatment discontinuation due to toxicity compared with non‐irinotecan‐containing regimens (very low certainty).
1 finding from 1 review
- OR 1 [0.46, 2.2]9 studies · 1979 participantsVery low
Topical quinolone vs quinolones
Suspected ototoxicity · people (of any age) with CSOM
1 finding from 1 review
- Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes onlyno estimate extracted3 studies · 265 participantsVery low
Cysteamine vs methionine (randomised trials)
Hepatotoxicity (aspartate aminotransferase > 1000 IU/L) · people with paracetamol (acetaminophen) overdose
It is very uncertain whether cysteamine changes hepatotoxicity (aspartate aminotransferase > 1000 U/L) compared with methionine (randomised trials) (very low certainty).
1 finding from 1 review
- OR 0.92 [0.05, 16.46]1 study · 27 participantsVery low
Cysteamine vs no intervention
Hepatotoxicity (aspartate aminotransferase > 1000 IU/L) · people with paracetamol (acetaminophen) overdose
Cysteamine may leads to lower hepatotoxicity (aspartate aminotransferase > 1000 IU/L) compared with no intervention (low certainty).
1 finding from 1 review
- OR 0.09 [0.02, 0.35]2 studies · 65 participantsLow
Retinoic acid post‐consolidation therapy vs no further treatment
Early toxicity ‐ not reported · high‐risk neuroblastoma patients treated with autologous HSCT
The review found no eligible studies for this question.
1 finding from 1 review
- Retinoic acid postconsolidation therapy for high‐risk neuroblastoma patients treated with autologous haematopoietic… 2017 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Retinoic acid post‐consolidation therapy vs no further treatment
Late toxicity including secondary malignancies ‐ not reported · high‐risk neuroblastoma patients treated with autologous HSCT
The review found no eligible studies for this question.
1 finding from 1 review
- Retinoic acid postconsolidation therapy for high‐risk neuroblastoma patients treated with autologous haematopoietic… 2017 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Topical quinolone vs intramuscular gentamicin
Suspected ototoxicity · adults with CSOM
1 finding from 1 review
- Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes onlyno estimate extracted1 study · 60 participantsVery low
Topical quinolone vs oral amoxicillin‐clavulanic acid combination
Suspected ototoxicity · adults with CSOM
1 finding from 1 review
- Topical versus systemic antibiotics for chronic suppurative otitis media 2021 · Cochrane Headline outcomes onlyno estimate extracted1 study · 56 participantsVery low
Topical quinolone vs povidone‐iodine
Suspected ototoxicity · chronic suppurative otitis media
It is very uncertain whether topical antibiotics (quinolones) changes suspected ototoxicity compared with povidone‐iodine (very low certainty).
1 finding from 1 review
- Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes onlyno estimate extracted1 study · 40 participantsVery low
Topical quinolone vs boric acid
Suspected ototoxicity ‐ not measured · chronic suppurative otitis media
The review found no eligible studies for this question.
1 finding from 1 review
- Antibiotics versus topical antiseptics for chronic suppurative otitis media 2020 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Summary of findings: Aminosalicylates vs placebo
Acute and late GI toxicity (grade 2+) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer
Summary of findings: Aminosalicylates probably leads to higher acute and late GI toxicity (grade 2+) compared with placebo (moderate certainty).
1 finding from 1 review
- Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes onlyRR 1.02 [1.22, 1.45]2 studies · 143 participantsModerate
Intervention not reported
Aminoglycoside antibiotics ‐ nephrotoxicity · patients with leading to fewer clinical adverse events
The intervention showed no clear difference in aminoglycoside antibiotics ‐ nephrotoxicity (low certainty).
1 finding from 1 review
- Computerized advice on drug dosage to improve prescribing practice 2013 · Cochrane Headline outcomes onlyRR 0.67 [0.42, 1.06]4 studies · 493 participantsLow
Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)
Hepatotoxicity · people with paracetamol (acetaminophen) overdose
It is very uncertain whether standard intravenous acetylcysteine regimen (20.5 hour) changes hepatotoxicity compared with shorter intravenous acetylcysteine regimen (12 hour) (very low certainty).
1 finding from 1 review
- OR 0.67 [0.11, 4.08]1 study · 202 participantsVery low
Oral vs intravenous acetylcysteine
Hepatotoxicity · people with paracetamol (acetaminophen) overdose
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Methionine and supportive treatment vs supportive treatment
Hepatotoxicity · people with paracetamol (acetaminophen) overdose
Methionine and supportive treatment may leads to lower hepatotoxicity compared with supportive treatment (low certainty).
1 finding from 1 review
- OR 0.05 [0.01, 0.53]1 study · 26 participantsLow
Initial infusion rate of intravenous acetylcysteine over 15 minutes vs 60 minutes
Hepatotoxicity · people with paracetamol (acetaminophen) overdose
It is very uncertain whether initial infusion rate of intravenous acetylcysteine over 15 minutes changes hepatotoxicity compared with 60 minutes (very low certainty).
1 finding from 1 review
- OR 1.34 [0.39, 4.56]1 study · 175 participantsVery low
Oral plus intravenous acetylcysteine vs intravenous acetylcysteine
Hepatotoxicity · people with paracetamol (acetaminophen) overdose
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings table (subcomparison 1): chemotherapy or targeted therapy plus best supportive care (BSC) vs BSC
Toxicity · palliative participants with esophageal and GE‐junction carcinoma
It is very uncertain whether summary of findings table (subcomparison 1): chemotherapy or… changes toxicity compared with BSC (very low certainty).
1 finding from 1 review
- Palliative chemotherapy and targeted therapies for esophageal and gastroesophageal junction cancer 2017 · Cochrane Headline outcomes onlyno estimate extracted3 studies · 972 participantsVery low
Summary of findings table (subcomparison 2): second‐line chemotherapy or targeted therapy agent(s) plus control intervention vs control intervention
Toxicity · palliative participants with esophageal and GE‐junction carcinoma previously treated with chemotherapy
It is very uncertain whether summary of findings table (subcomparison 2): second‐line… changes toxicity compared with control intervention alone (very low certainty).
1 finding from 1 review
- Palliative chemotherapy and targeted therapies for esophageal and gastroesophageal junction cancer 2017 · Cochrane Headline outcomes onlyno estimate extracted4 studies · 1638 participantsVery low