Findings

What do systematic reviews say?

6 questions · 6 findings · 6 reviews · Stroke

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 2 · 33.3%Moderate 1 · 16.7%High 2 · 33.3%

Intravenous thrombolytic treatment vs standard‐of‐care therapy

Symptomatic intracranial haemorrhage at · people with stroke upon awakening

Intravenous thrombolytic treatment showed no clear difference in symptomatic intracranial haemorrhage at compared with standard medical care (high certainty).

1 finding from 1 review

Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake‐up stroke 2021 · Cochrane Headline outcomes only
RR 3.47 [0.98, 12.26]
4 studies · 754 participants
High

Endovascular thrombectomy interventions vs usual care

Symptomatic intracranial haemorrhage at · acute ischaemic stroke

Endovascular thrombectomy interventions showed no clear difference in symptomatic intracranial haemorrhage at the end of compared with standard therapy (high certainty).

1 finding from 1 review

Endovascular thrombectomy and intra‐arterial interventions for acute ischaemic stroke 2021 · Cochrane Headline outcomes only
RR 1.05 [0.72, 1.52]
10 studies · 1752 participants
High

Percutaneous vascular interventions vs intravenous thrombolytic treatment

Symptomatic intracranial haemorrhage at

Percutaneous vascular interventions showed no clear difference in symptomatic intracranial haemorrhage within first 14 days compared with intravenous thrombolytic treatment (low certainty).

1 finding from 1 review

Percutaneous vascular interventions versus intravenous thrombolytic treatment for acute ischaemic stroke 2018 · Cochrane Headline outcomes only
RR 0.99 [0.5, 1.95]
4 studies · 450 participants
Low

Antiplatelet drug vs control

Symptomatic intracranial haemorrhage during treatment period · acute ischaemic stroke

It is very uncertain whether antiplatelet drug changes symptomatic intracranial haemorrhage during treatment period compared with control (very low certainty).

1 finding from 1 review

Oral antiplatelet therapy for acute ischaemic stroke 2022 · Cochrane Headline outcomes only
Peto OR 1.18 [0.97, 1.44]
9 studies · 41652 participants
Very low

Anticoagulant vs control

Symptomatic intracranial haemorrhage during treatment period · acute presumed ischaemic stroke

Summary of findings table ‐ Anticoagulant probably leads to higher symptomatic intracranial haemorrhage during treatment period compared with control (moderate certainty).

1 finding from 1 review

Anticoagulants for acute ischaemic stroke 2021 · Cochrane Headline outcomes only
OR 2.47 [1.9, 3.21]
21 studies · 23221 participants
Moderate

Low‐molecular‐weight heparins or heparinoids vs unfractionated heparin

Symptomatic intracranial haemorrhage/haemorrhagic transformation of the cerebral infarct during treatment period (range 6 days to 16 days)⁹ · acute ischaemic stroke

Low‐molecular‐weight heparins or heparinoids showed no clear difference in symptomatic intracranial haemorrhage/haemorrhagic transformation of… compared with unfractionated heparin (low certainty).

1 finding from 1 review

Low‐molecular‐weight heparins or heparinoids versus standard unfractionated heparin for acute ischaemic stroke 2017 · Cochrane Headline outcomes only
OR 0.73 [0.35, 1.54]
8 studies · 3102 participants
Low