Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

17 questions · 17 findings · 12 reviews · Heart

No studies found 2 · 11.8%GRADE not reported 1 · 5.9%Very low 4 · 23.5%Low 5 · 29.4%Moderate 3 · 17.6%High 2 · 11.8%

Higher vs lower omega‐6: additional key outcomes

Fatal or nonfatal stroke · adults with or without existing CVD

It is very uncertain whether higher changes stroke: fatal or non‐fatal Study duration range 24‐96 months Omega‐6… compared with lower omega‐6: primary outcomes (very low certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Stroke · people with or without existing cardiovascular disease, men and women

It is very uncertain whether homocysteine‐lowering interventions (high dose) changes stroke compared with homocysteine‐lowering interventions (low dose) (very low certainty).

1 finding from 1 review

clopidogrel plus aspirin vs aspirin

Fatal and non‐fatal ischaemic stroke · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease

clopidogrel plus aspirin probably leads to lower fatal and non‐fatal ischaemic stroke compared with aspirin alone (moderate certainty).

1 finding from 1 review

Transcendental meditation (TM) vs active comparators

Clinical CVD events (CVD mortality, non‐fatal MI and stroke, revascularisations) · people at high risk of or withcardiovascular disease

Transcendental meditation (TM) showed no clear difference in clinical CVD events (CVD mortality, non‐fatal MI and stroke,… compared with active comparators (low certainty).

1 finding from 1 review