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Evidence found and GRADE certainty

16 questions · 17 findings · 3 reviews · Schizophrenia

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 12 · 70.6%Low 5 · 29.4%Moderate 0 · 0%High 0 · 0%

RISPERIDONE vs haloperidol

Specific behaviour ‐ agitation · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether RISPERIDONE changes specific behaviour: agitation, up to 24 hours (PANSS‐PAS response) compared with OTHER ANTIPSYCHOTIC: a. HALOPERIDOL (very low certainty).

1 finding from 1 review

ARIPIPRAZOLE (IM) vs OLANZAPINE

Specific behaviour: Agitation ‐ clinically important change (PANSS ‐EC reduction ≥ 40% from baseline) ‐ up to 2 hours · psychosis‐induced aggression or agitation (rapid tranquillisation)

ARIPIPRAZOLE (IM) may leads to lower specific behaviour: Agitation ‐ clinically important change (PANSS… compared with OTHER ANTIPSYCHOTIC: b. OLANZAPINE (low certainty).

1 finding from 1 review

ARIPIPRAZOLE (IM) vs PLACEBO/NIL

Specific behaviour: Agitation ‐ clinically important change (PANSS ‐EC reduction ≥ 40% from baseline) ‐ up to 2 hours · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether ARIPIPRAZOLE (IM) changes specific behaviour: Agitation ‐ clinically important change (PANSS… compared with PLACEBO/NIL (very low certainty).

1 finding from 1 review

ARIPIPRAZOLE (IM) vs haloperidol

Specific behaviour: Agitation ‐ clinically important change (PANSS ‐EC reduction ≥ 40% from baseline) ‐ up to 2 hours · psychosis‐induced aggression or agitation (rapid tranquillisation)

It is very uncertain whether ARIPIPRAZOLE (IM) changes specific behaviour: Agitation ‐ clinically important change (PANSS… compared with OTHER ANTIPSYCHOTIC: a. HALOPERIDOL (very low certainty).

1 finding from 1 review

HALOPERIDOL vs RISPERIDONE

Specific behaviours ‐ agitation >50% reduction in PANSS‐EC score · patients with psychosis‐induced aggression or agitation

HALOPERIDOL showed no clear difference in specific behaviours ‐ agitation >50% reduction in PANSS‐EC score compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: d. QUETIAPINE + MAGNESIUM VALPROATE

Specific behaviour ‐ agitation · patients with psychosis‐induced aggression or agitation
2 findings from 1 review