HALOPERIDOL vs COMBINATIONS: d. QUETIAPINE + MAGNESIUM VALPROATE: Specific behaviour ‐ agitation
- Population
- patients with psychosis‐induced aggression or agitation
- Intervention
- HALOPERIDOL
- Comparison
- COMBINATIONS: d. QUETIAPINE + MAGNESIUM VALPROATE
- Outcome
- Specific behaviour ‐ agitation
It is very uncertain whether HALOPERIDOL changes global effect Specific behaviour ‐ agitation ‐ no effect based on… compared with COMBINATIONS: g. QUETIAPINE + MAGNESIUM VALPROATE (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
HALOPERIDOL vs COMBINATIONS: g. QUETIAPINE + MAGNESIUM VALPROATE Specific behaviours ‐ agitation at 3 days average endpoint score (PANSS‐EC) · patients with psychosis‐induced aggression or agitation Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) (2017) · Cochrane Headline outcomes only | no estimate extracted | 1 study · 60 participants | Very low |
HALOPERIDOL vs COMBINATIONS: g. QUETIAPINE + MAGNESIUM VALPROATE Global effect Specific behaviour ‐ agitation ‐ no effect based on PANSS‐EC (< 25% decrease) · patients with psychosis‐induced aggression or agitation It is very uncertain whether HALOPERIDOL changes global effect Specific behaviour ‐ agitation ‐ no effect based on… compared with COMBINATIONS: g. QUETIAPINE + MAGNESIUM VALPROATE (very low certainty). Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) (2017) · Cochrane Headline outcomes only | RR 1.17 [0.44, 3.06] | 1 study · 60 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- HALOPERIDOL vs RISPERIDONE · terminally ill adults with delirium · 1 review
- HALOPERIDOL vs OLANZAPINE · terminally ill adults with delirium · 1 review
- HALOPERIDOL vs chlorpromazine · terminally ill adults with delirium · 1 review
- HALOPERIDOL vs placebo · terminally ill adults with delirium · 1 review
- HALOPERIDOL vs lorazepam · terminally ill adults with delirium · 1 review
- HALOPERIDOL vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM · psychosis‐induced aggression or agitation · 1 review
- HALOPERIDOL vs COMBINATIONS: h. RISPERIDONE + CLONAZEPAM · psychosis‐induced aggression or agitation · 1 review
- HALOPERIDOL vs ZIPRASIDONE · psychosis‐induced aggression or agitation · 1 review
- HALOPERIDOL vs COMBINATIONS: e. HALOPERIDOL + RISPERIDONE · psychosis‐induced aggression or agitation · 1 review
- HALOPERIDOL vs COMBINATIONS: f. OLANZAPINE + MAGNESIUM VALPROATE · psychosis‐induced aggression or agitation · 1 review
- HALOPERIDOL vs COMBINATIONS: i. ZIPRASIDONE + CLONAZEPAM · psychosis‐induced aggression or agitation · 1 review
- HALOPERIDOL vs QUETIAPINE · psychosis‐induced aggression or agitation · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.