ARIPIPRAZOLE (IM) vs PLACEBO/NIL: Specific behaviour: Agitation ‐ clinically important change (PANSS ‐EC reduction ≥ 40% from baseline) ‐ up to 2 hours
- Population
- psychosis‐induced aggression or agitation (rapid tranquillisation)
- Intervention
- ARIPIPRAZOLE (IM)
- Comparison
- PLACEBO/NIL
- Outcome
- Specific behaviour: Agitation ‐ clinically important change (PANSS ‐EC reduction ≥ 40% from baseline) ‐ up to 2 hours
It is very uncertain whether ARIPIPRAZOLE (IM) changes specific behaviour: Agitation ‐ clinically important change (PANSS… compared with PLACEBO/NIL (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
ARIPIPRAZOLE (IM) vs PLACEBO/NIL Specific behaviour: Agitation ‐ clinically important change (PANSS ‐EC reduction ≥ 40% from baseline) ‐ up to 2 hours · psychosis‐induced aggression or agitation (rapid tranquillisation) It is very uncertain whether ARIPIPRAZOLE (IM) changes specific behaviour: Agitation ‐ clinically important change (PANSS… compared with PLACEBO/NIL (very low certainty). Aripiprazole (intramuscular) for psychosis‐induced aggression or agitation (rapid tranquillisation) (2018) · Cochrane Headline outcomes only | RR 1.5 [1.17, 1.92] | 2 studies · 382 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Aripiprazole (intramuscular) for psychosis‐induced aggression or agitation (rapid tranquillisation) 2018 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- ARIPIPRAZOLE (IM) vs haloperidol · psychosis‐induced aggression or agitation (rapid tranquillisation) · 1 review
- ARIPIPRAZOLE (IM) vs OLANZAPINE · psychosis‐induced aggression or agitation (rapid tranquillisation) · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.