Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

59 questions · 59 findings · 37 reviews

No studies found 11 · 18.6%GRADE not reported 8 · 13.6%Very low 23 · 39%Low 12 · 20.3%Moderate 3 · 5.1%High 2 · 3.4%

Intervention not reported

There was no evidence of differences in the proportion of participants experiencing serious adverse events (for any of the comparisons Quality of evidence = very low1,2,3. · people undergoing liver resection
1 finding from 1 review

Anti‐TNF discontinuation vs anti‐TNF continuation

Number of serious adverse events · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

It is very uncertain whether anti‐TNF discontinuation changes number of serious adverse events compared with anti‐TNF continuation (very low certainty).

1 finding from 1 review

Anti‐TNF disease activity–guided dose tapering vs anti‐TNF continuation

Number of serious adverse events · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

It is very uncertain whether anti‐TNF disease activity–guided dose tapering changes number of serious adverse events compared with anti‐TNF continuation (very low certainty).

1 finding from 1 review

Anti‐TNF dose reduction vs anti‐TNF continuation

Number of serious adverse events · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

Anti‐TNF dose reduction showed no clear difference in number of serious adverse events compared with anti‐TNF continuation (low certainty).

1 finding from 1 review

Paracetamol vs placebo

Serious adverse events Up to 12 weeks' · Patients with acute low‐back pain

Paracetamol showed no clear difference in serious adverse events Up to 12 weeks' compared with placebo (moderate certainty).

1 finding from 1 review