Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

13 questions · 13 findings · 8 reviews · Headline outcomes only

No studies found 5 · 38.5%GRADE not reported 1 · 7.7%Very low 2 · 15.4%Low 1 · 7.7%Moderate 3 · 23.1%High 1 · 7.7%

Vitamin D vs placebo

Proportion of participants with one or more serious adverse events due to any cause · children and adults with predominantly mild to moderate asthma

Summary of findings table ‐ Vitamin D showed no clear difference in proportion of participants with one or more serious adverse events… compared with placebo (high certainty).

1 finding from 1 review

Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo

Number of participants experiencing any serious adverse events · people with Alzheimer's disease

Vitamin E (capsules 2000 IU/day in two divided doses) showed no clear difference in adverse events Number of participants reporting ≥ 1 serious adverse… compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · [People] with [Multiple Sclerosis]
1 finding from 1 review