Cochrane · systematic review · CD015043
Vitamin D supplementation for the treatment of COVID‐19: a living systematic review
Stroehlein, JK, Wallqvist, J, Iannizzi, C, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
3
No studies
3
Included studies
NR
No studies 3 · 50%Ungraded 0 · 0%Very low 2 · 33.3%Low 1 · 16.7%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of Findings Table ‐ Vitamin D compared to placebo or standard care alone for individuals with moderate to severe disease
Population: individualswith moderate to severe disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality at hospital discharge Summary of Findings Table ‐ Vitamin D vs placebo or standard care alone | no estimate extracted | 2 studies · 313 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Improvement of clinical status Summary of Findings Table ‐ Vitamin D vs placebo or standard care alone | no estimate extracted | NR | No studies |
Worsening of clinical status Summary of Findings Table ‐ Vitamin D vs placebo or standard care alone | RR 0.52 [0.24, 1.13] | 1 study · 237 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Quality of life, including fatigue and neurological status Summary of Findings Table ‐ Vitamin D vs placebo or standard care alone | no estimate extracted | NR | No studies |
Adverse events (any grade) Summary of Findings Table ‐ Vitamin D vs placebo or standard care alone | RR 2.98 [0.12, 72.3] | 1 study · 237 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Serious adverse events Summary of Findings Table ‐ Vitamin D vs placebo or standard care alone | no estimate extracted | NR | No studies |