Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

189 questions · 190 findings · 62 reviews

No studies found 72 · 37.9%GRADE not reported 11 · 5.8%Very low 59 · 31.1%Low 28 · 14.7%Moderate 15 · 7.9%High 5 · 2.6%

Leflunomide vs methotrexate

Serious adverse events* · adults with renal vasculitis for maintenance therapy

Leflunomide showed no clear difference in serious adverse events* compared with methotrexate (low certainty).

1 finding from 1 review

Plasma‐derived C1 esterase inhibitor vs placebo or active control

Serious adverse events (during · children or adults with Types I or II HAE

It is very uncertain whether plasma‐derived C1 esterase inhibitor changes serious adverse events (during compared with placebo or active control (very low certainty).

1 finding from 1 review

Recombinant human C1 esterase inhibitor vs placebo or active control

Serious adverse events (during · children or adults with Types I or II HAE

It is very uncertain whether recombinant human C1 esterase inhibitor changes serious adverse events (during compared with placebo or active control (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events (number) · people with acute pancreatitis
1 finding from 1 review