Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

271 questions · 282 findings · 120 reviews

No studies found 54 · 19.1%GRADE not reported 16 · 5.7%Very low 81 · 28.7%Low 75 · 26.6%Moderate 39 · 13.8%High 17 · 6%

Usual care vs immunosuppressive withdrawal after combination therapy

Serious adverse events · Participants with Crohn's disease in remission

It is very uncertain whether usual care changes serious adverse events compared with immunosuppressive withdrawal after combination therapy (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · people with pressure ulcers

It is very uncertain whether the intervention changes serious adverse events (very low certainty).

1 finding from 1 review

Non‐absorbable disaccharides vs placebo or no intervention

Serious adverse events · prevention and treatment of hepatic encephalopathy in people with cirrhosis

Non‐absorbable disaccharides probably leads to lower serious adverse events compared with placebo/no intervention (moderate certainty).

1 finding from 1 review

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Serious adverse events · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids probably leads to higher serious adverse events compared with moderate‐dose or no corticosteroids (moderate certainty).

1 finding from 1 review

Fluoroquinolone substitution for ethambutol in a standard six month regimen vs standard regimen

Serious adverse events · Patients with presumed drug‐sensitive TB

It is very uncertain whether fluoroquinolone substitution for ethambutol in a standard six month… changes serious adverse events compared with standard regimen (very low certainty).

1 finding from 1 review

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

Serious adverse events · Patients with presumed drug‐sensitive TB

Fluoroquinolone substitution for isoniazid in a standard six month… showed no clear difference in serious adverse events compared with standard regimen (low certainty).

1 finding from 1 review

Summary of findings table ‐ Oral small molecule inhibitors (apremilast or baricitinib) vs placebo

Incidence of serious adverse events · adults with alopecia areata

Summary of findings table ‐ Oral small molecule inhibitors… showed no clear difference in incidence of serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Non‐serious adverse events · people with pressure ulcers

The intervention may leads to higher non‐serious adverse events (low certainty).

1 finding from 1 review

Intervention not reported

Other serious adverse events · people with osteoporotic vertebral compression fracture

The intervention showed no clear difference in other serious adverse events (low certainty).

1 finding from 1 review