Cochrane · systematic review · CD014804
Synbiotics, prebiotics and probiotics for solid organ transplant recipients
Cooper, TE, Scholes-Robertson, N, Craig, JC, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
4
No studies
12
Included studies
NR
No studies 12 · 75%Ungraded 0 · 0%Very low 4 · 25%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Synbiotics versus placebo for solid organ transplant recipients
Population: adult solid organ transplant recipients (kidney)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
GI function Synbiotics vs placebo | no estimate extracted | NR | No studies |
Graft health Synbiotics vs placebo | no estimate extracted | NR | No studies |
Adverse events Synbiotics vs placebo | no estimate extracted | NR | No studies |
Serious adverse events Synbiotics vs placebo | no estimate extracted | NR | No studies |
Death Synbiotics vs placebo | no estimate extracted | NR | No studies |
Probiotics versus placebo for solid organ transplant recipients
Population: adult solid organ transplant recipients (liver)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
GI function Probiotics vs placebo | no estimate extracted | NR | No studies |
Graft health Probiotics vs placebo | no estimate extracted | NR | No studies |
Adverse events Probiotics vs placebo | no estimate extracted | NR | No studies |
Serious adverse events Probiotics vs placebo | no estimate extracted | NR | No studies |
Death Probiotics vs placebo | no estimate extracted | NR | No studies |
Synbiotics versus prebiotics for solid organ transplant recipients
Population: adult solid organ transplant recipients (liver)
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
GI function Synbiotics vs prebiotics | no estimate extracted | NR | No studies |
Graft health: acute liver rejection Synbiotics vs prebiotics | RR 0.73 [0.43, 1.25] | 2 studies · 129 participants | Very low Downgraded: risk of bias, imprecision |
Graft health Synbiotics vs prebiotics | no estimate extracted | NR | No studies |
Adverse events Synbiotics vs prebiotics | RR 0.79 [0.4, 1.59] | 2 studies · 129 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events Synbiotics vs prebiotics | RR 1.49 [0.42, 5.36] | 2 studies · 129 participants | Very low Downgraded: risk of bias, imprecision |
Death Synbiotics vs prebiotics | no estimate extracted | 2 studies · 129 participants | Very low Downgraded: risk of bias, imprecision |