Findings

What do systematic reviews say?

16 questions · 16 findings · 11 reviews · Headline outcomes only

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No studies found 12 · 75%GRADE not reported 0 · 0%Very low 1 · 6.3%Low 1 · 6.3%Moderate 2 · 12.5%High 0 · 0%

Hypertonic saline vs Normal saline

SGRQ Total SGRQ (Total) Score. Scale from: 0 to 100. Lower score indicates better quality of life. · people with bronchiectasis

1 finding from 1 review

Inhaled hyperosmolar agents for bronchiectasis 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Moderate

Sclerotherapy (hypertonic saline) vs sclerotherapy (any sclerosant)

Quality of life · people with telangiectasias and reticular veins

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for telangiectasias and reticular veins 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Saline irrigation plus pharmacological treatment vs pharmacological treatment alone

Health‐related quality of life (4 weeks to 6 months) · allergic rhinitis

1 finding from 1 review

Saline irrigation for allergic rhinitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Injectional nicardipine vs Normal saline

Quality of life · men with chronic Peyronie's disease (plaques without calcification)

The review found no eligible studies for this question.

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Injectional betamethasone vs Normal saline

Quality of life · men with Peyronie's disease (not defined)

The review found no eligible studies for this question.

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Injectional verapamil vs saline (short‐term)

Quality of life · men with Peyronie's disease (palpable plaque or pain)

The review found no eligible studies for this question.

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Injectional interferon alpha‐2B vs Normal saline

Quality of life · men with chronic (≥ 12 months) Peyronie's disease (single plaque)

The review found no eligible studies for this question.

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

RBD‐specific polyclonal F(ab') 2 fragments of equine antibodies (EpAbs) vs saline placebo

Quality of life · individuals with moderate or severe COVID‐19

The review found no eligible studies for this question.

1 finding from 1 review

Hyperimmune immunoglobulin for people with COVID‐19 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hyperimmune immunoglobulin from human plasma vs saline placebo

Quality of life · individuals with moderate or severe COVID‐19

The review found no eligible studies for this question.

1 finding from 1 review

Hyperimmune immunoglobulin for people with COVID‐19 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Local corticosteroid injection (LCI) vs saline no treatment or placebo

Improvement in quality of life · carpal tunnel syndrome

1 finding from 1 review

Local corticosteroid injection versus placebo for carpal tunnel syndrome 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 111 participants
Moderate

Hydrogel dressings vs saline gauze

Health‐related quality of life · people with venous leg ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Hydrogel dressings for venous leg ulcers 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Propyl betaine and polihexanide vs Normal saline

Health related quality of life · participants with chronic leg ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Wound cleansing for treating venous leg ulcers 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Polyhexamethylene biguanide (PHMB) vs Normal saline

Health related quality of life · people with venous leg ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Wound cleansing for treating venous leg ulcers 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Gemcitabine vs Normal saline

Disease‐specific quality of life · patients with non‐muscle invasive bladder cancer

The review found no eligible studies for this question.

1 finding from 1 review

Intravesical gemcitabine for non‐muscle invasive bladder cancer 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical phenytoin vs saline dressing

Secondary outcome: quality of life · ulceration and other skin changes caused by nerve damage in leprosy

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for ulceration and other skin changes caused by nerve damage in leprosy 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Dornase alfa vs hypertonic saline

Mean relative percentage in quality of life score at 3 months · children with cystic fibrosis

Dornase alfa showed no clear difference in mean relative percentage in quality of life score at 3 months compared with hypertonic saline (low certainty).

1 finding from 1 review

Dornase alfa for cystic fibrosis 2021 · Cochrane Headline outcomes only
MD 0.03
431 participants
Low