Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

530 questions · 544 findings · 235 reviews · Headline outcomes only

No studies found 291 · 53.5%GRADE not reported 31 · 5.7%Very low 87 · 16%Low 83 · 15.3%Moderate 42 · 7.7%High 10 · 1.8%

Augmentation of current antidepressant (SSRI) with ziprasidone (40 mg/d to 160 mg/d) vs augmentation of current antidepressant (SSRI) with placebo or continue on SSRI monotherapy

Quality of life ‐ not measured · treatment‐resistant depression in adults

The review found no eligible studies for this question.

1 finding from 1 review

Augmentation of current antidepressant (fluoxetine 20 mg/d to 60 mg/d) with olanzapine (5 mg/d to 20 mg/d) vs augmentation of current antidepressant (fluoxetine 20 mg/d to 60 mg/d) with placebo

Quality of life ‐ not measured · treatment‐resistant depression in adults

The review found no eligible studies for this question.

1 finding from 1 review