Findings

What do systematic reviews say?

140 questions · 142 findings · 71 reviews

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No studies found 55 · 38.7%GRADE not reported 13 · 9.2%Very low 19 · 13.4%Low 29 · 20.4%Moderate 23 · 16.2%High 3 · 2.1%

Summary of findings table ‐ Energy, protein and micronutrients vs standard diet

Health‐related quality of life ‐ not reported · long‐term care patients; inpatients without dehydration with energy intake by tube feeding; patients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Nutritional interventions for preventing and treating pressure ulcers 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Protein, arginine, zinc and antioxidants vs standard diet or placebo

Health‐related quality of life ‐ not reported · residents of long‐term care (≥ 65 years) with pressure ulcers; inpatients with pressure ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Nutritional interventions for preventing and treating pressure ulcers 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Paliperidone palmitate vs risperidone long‐acting injection

Health related quality of life ‐ not measured · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

Paliperidone palmitate for schizophrenia 2012 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Professional oral care vs Usual oral care

Change in data on economics and quality of life · Residents of nursing homes and other long-term care facilities

Professional oral care led to higher change in data on economics and quality of life compared with usual oral care; GRADE not reported.

1 finding from 1 review

Oral care measures for preventing nursing home‐acquired pneumonia 2022 · Cochrane All outcomes
24 months
MD 1.5 [0.32, 2.68]
1 study · 322 participants
GRADE not reported

Intervention not reported

Quality of life (3‐6 months) · older adults with functional dependence

It is very uncertain whether the intervention changes quality of life (3‐6 months) (very low certainty).

1 finding from 1 review

Home or foster home care versus institutional long‐term care for functionally dependent older people 2017 · Cochrane Headline outcomes only
RR 1.97
2 studies · 114 participants
Very low

Summary of findings: insulin detemir vs NPH insulin

Health‐related quality of life

2 findings from 2 reviews · compare the 2 reviews

(Ultra‐)long‐acting insulin analogues for people with type 1 diabetes mellitus 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 870 participants
Low
(Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes… 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 873 participants
Very low

Personally tailored activities vs usual care or non‐personalised activities

Quality of life (proxy‐rating; · people with dementia

1 finding from 1 review

Personally tailored activities for improving psychosocial outcomes for people with dementia in long‐term care 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 177 participants
Low

Summary of findings: insulin detemir vs insulin glargine

Health‐related quality of life

The review found no eligible studies for this question.

1 finding from 1 review

(Ultra‐)long‐acting insulin analogues for people with type 1 diabetes mellitus 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Direct oral anticoagulant secondary prophylaxis vs vitamin K antagonist secondary prophylaxis

Health related quality of life · patients with active cancer with venous thromboembolism

1 finding from 1 review

Anticoagulation for the long‐term treatment of venous thromboembolism in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 8485 participants
Moderate

Indacaterol vs long‐acting beta2‐agonist alone

Quality of life: number of participants with clinically significant improvement (≥ 4 units) in SGRQ total score · patients with chronic obstructive pulmonary disease

Indacaterol showed no clear difference in number of participants with a clinically significant improvement in… compared with twice‐daily long‐acting beta2‐agonists (moderate certainty).

1 finding from 1 review

Indacaterol, a once‐daily beta₂‐agonist, versus twice‐daily beta₂‐agonists or placebo for chronic obstructive… 2015 · Cochrane Headline outcomes only
OR 1.07 [0.87, 1.32]
2 studies · 1520 participants
Moderate

Tiotropium + LABA/ICS combination vs tiotropium

Quality of life St George's Respiratory Questionnaire (SGRQ) score · patients with chronic obstructive pulmonary disease

1 finding from 1 review

Combination inhaled steroid and long‐acting beta₂‐agonist in addition to tiotropium versus tiotropium or combination… 2016 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 4 participants
Low

Whole‐facility changes: Home‐like models vs traditional environment

Health‐related quality of life Dementia‐specific quality of life measure (QUALIDEM) (higher scores = better) · older adults living in long‐term residential care including, but not limited to, dementia‐specific care settings

1 finding from 1 review

Physical environmental designs in residential care to improve quality of life of older people 2022 · Cochrane Headline outcomes only
no estimate extracted
33 participants
Very low

Stopping LABA vs continuing use of LABA+ICS

Asthma‐related quality of life (MCID) · adults with asthma well controlled on LABA and ICS

1 finding from 1 review

Stopping long‐acting beta₂‐agonists (LABA) for adults with asthma well controlled by LABA and inhaled corticosteroids 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 359 participants
Moderate

Intervention not reported

Quality of life (dyspnoea) Measured on the CRQ, the output is a number from 0 to 7, where higher on the scale is better. MID is 0.5. · adults with COPD who had exertional dyspnoea but did not fulfil the criteria for long‐term oxygen treatment

The intervention probably leads to higher quality of life (dyspnoea) Measured on the CRQ, the output is a… (moderate certainty).

1 finding from 1 review

Ambulatory oxygen for people with chronic obstructive pulmonary disease who are not hypoxaemic at rest 2014 · Cochrane Headline outcomes only
MD 0.28 [0.1, 0.45]
4 studies · 341 participants
Moderate

Summary of findings: anti‐pseudomonal antibiotics vs placebo

Quality of life: lost school or working days · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

1 finding from 1 review

Inhaled anti‐pseudomonal antibiotics for long‐term therapy in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 245 participants
Low

Idraparinux secondary prophylaxis vs vitamin K antagonist secondary prophylaxis

Health‐related quality of life ‐ not reported · people with cancer with VTE receiving secondary prophylaxis

The review found no eligible studies for this question.

1 finding from 1 review

Anticoagulation for the long‐term treatment of venous thromboembolism in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: levofloxacin for inhalation solution vs tobramycin

Quality of life: change from baseline in CFQ‐R · adults and children aged over 12 with CF and P aeruginosa

1 finding from 1 review

Inhaled anti‐pseudomonal antibiotics for long‐term therapy in cystic fibrosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 282 participants
Low

Intervention not reported

PC‐QOL mean score at 6 weeks PC‐QOL is a 27‐item questionnaire. Each question has a 7‐point score ranging from 1 (worst quality of life) to 7 (best quality of life). Scores for each item were added and the average taken · children with chronic cough of unknown origin lasting longer than 4 weeks

The intervention probably leads to higher PC‐QOL mean score at 6 weeks PC‐QOL is a 27‐item questionnaire. Each… (moderate certainty).

1 finding from 1 review

Clinical pathways for chronic cough in children 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 226 participants
Moderate

Personally tailored activities vs usual care or non‐personalised activities

Quality of life (self‐rating by the participants; · people with dementia

1 finding from 1 review

Personally tailored activities for improving psychosocial outcomes for people with dementia in long‐term care 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 42 participants
Low

Recombinant human C1 esterase inhibitor vs placebo or active control

Differences in quality of life ( · children or adults with Types I or II HAE

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for the long‐term prevention of hereditary angioedema attacks 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found