Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

100 questions · 116 findings · 41 reviews

No studies found 48 · 41.4%GRADE not reported 21 · 18.1%Very low 12 · 10.3%Low 16 · 13.8%Moderate 17 · 14.7%High 2 · 1.7%

Summary of findings ‐ triple therapy: elexacaftor‐tezacaftor‐ivacaftor vs control (ivacaftor alone or tezacaftor plus ivacaftor)

Quality of life: total score · adults and children aged 12 years and over with cystic fibrosis and either F508del/gating variant or F508del/residual function genotype

The review found no eligible studies for this question.

1 finding from 1 review

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

Quality of life ‐ not reported · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Health‐related quality of life · individuals without known diabetes mellitus but at high risk for the condition

The review found no eligible studies for this question.

1 finding from 1 review