What do systematic reviews say?

Silver diamine fluoride (SDF, including SDF + fluoride varnish) vs Other standard-of-care caries treatments pooled (placebo, ART, or ART + fluoride varnish)

SDF had no significant effect on oral health-related quality of life versus pooled standard-of-care caries treatments (SMD -0.06, 95% CI -0.20 to 0.08; ungraded).

• Silver diamine fluoride and oral health-related quality of life: A review and network meta-analysis. 2022 All outcomes

  Post-treatment (follow-up varied by trial) · Pediatric dental care; trials conducted in China, the USA, and Brazil
  SMD -0.06 [-0.20, 0.08]
  5 studies · 820 participants
  GRADE not reported

Vitamin D vs placebo or usual care

The review found no eligible studies for this question.

• Vitamin D supplementation for the treatment of COVID‐19: a living systematic review 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Iron therapy vs No treatment, placebo, usual care, or another oral care measure

• Iron therapy for preoperative anaemia 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 72 participants
  Very low

Transarterial embolisation vs no intervention

The review found no eligible studies for this question.

• Transarterial (chemo)embolisation versus no intervention or placebo for liver metastases 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Transarterial chemoembolisation vs no intervention

The review found no eligible studies for this question.

• Transarterial (chemo)embolisation versus no intervention or placebo for liver metastases 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Transarterial embolisation and transarterial chemoembolisation vs no intervention

The review found no eligible studies for this question.

• Transarterial (chemo)embolisation versus no intervention or placebo for liver metastases 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Zinc oxide mesh vs placebo mesh

The review found no eligible studies for this question.

• Dressings and topical agents for the management of open wounds after surgical treatment for sacrococcygeal pilonidal… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Omega‐3 vs placebo

• Interventions for prodromal stage of psychosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Group B antipsychotic drugs: olanzapine + supportive intervention vs placebo or supportive treatment

• Interventions for prodromal stage of psychosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Group A: amino acids vs placebo

• Interventions for prodromal stage of psychosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Cannabis cigarettes vs placebo

The review found no eligible studies for this question.

• Cannabis for the treatment of ulcerative colitis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

SPRM vs placebo

• Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 200 participants
  Moderate

Amifostine vs no treatment/placebo

It is very uncertain whether amifostine changes quality of life (Patient Benefit Questionnaire, 10-point scale) compared with no treatment/placebo (very low certainty).

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes

  12 months postRT
  MD 0.70 [0.20, 1.20]
  1 study · 180 participants
  Very low

Spironolactone 100 mg vs placebo

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Finasteride 5 mg to 7.5 mg vs placebo

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin 500 mg to 2550 mg per day vs placebo

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Flutamide 250 mg b.i.d. vs placebo

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Porter 2020: armodafinil vs placebo

• Interventions for the management of fatigue in adults with a primary brain tumour 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 232 participants
  Low

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

• Interventions for the eradication of meticillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 25 participants
  Very low

Donepezil 10 mg/day vs placebo

• Donepezil for dementia due to Alzheimer's disease 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 815 participants
  Moderate