What do systematic reviews say?

Oral iron vs inactive control

• Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 276 participants
  Very low

Intervention not reported

The review found no eligible studies for this question.

• Electrotherapy for neck pain 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Electrotherapy for neck pain 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Interventions for improving adherence to ocular hypotensive therapy 2013 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 265 participants
  Very low

Intervention not reported

The review found no eligible studies for this question.

• Interventions for improving adherence to ocular hypotensive therapy 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Occupational therapy for care home residents with stroke 2013 · Cochrane Headline outcomes only
  no estimate extracted
  0 participants
  GRADE not reported

Stabilisation splint (SS) vs Non-occluding splint

Stabilisation splint (SS) led to lower quality of life compared with non-occluding splint; GRADE not reported.

• Stabilisation splint therapy for temporomandibular pain dysfunction syndrome 2004 · Cochrane All outcomes

  3 months or less
  RR 0.12 [0.02, 0.90]
  1 study
  GRADE not reported

Amifostine vs no treatment/placebo

It is very uncertain whether amifostine changes quality of life (Patient Benefit Questionnaire, 10-point scale) compared with no treatment/placebo (very low certainty).

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes

  12 months postRT
  MD 0.70 [0.20, 1.20]
  1 study · 180 participants
  Very low

Biofeedback vs hypnotherapy

The review found no eligible studies for this question.

• Biofeedback for treatment of irritable bowel syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Selenium vs no intervention

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes

  6 weeks after end of RT
  Insufficient evidence of differences for loss of taste or dysphagia; data largely unusable (no standard deviations). Ageusia milder in selenium group (not significant); dysphagia significant only at week 7 (P = 0.05)…
  1 study
  GRADE not reported

Local excision vs radical resection

• Local versus radical surgery for early rectal cancer with or without neoadjuvant or adjuvant therapy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 55 participants
  Low

Intervention not reported

• Chemotherapy with cetuximab versus chemotherapy alone for chemotherapy‐naive advanced non‐small cell lung cancer 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1801 participants
  Low

Any antifungal intervention for the treatment of oral candidiasis vs Placebo, no treatment, or another active antifungal intervention

The review found no eligible studies for this question.

• Interventions for treating oral candidiasis for patients with cancer receiving treatment 2010 · Cochrane All outcomes
  None of the studies reported: relief of pain, relief of dysphagia, incidence of systemic infection, amount of analgesia, days stay in hospital, cost of oral care, patient quality of life.
  0 studies
  No studies found

Antifungal drugs absorbed from GI tract (fluconazole, ketoconazole, itraconazole) vs placebo or no treatment

The review found no eligible studies for this question.

• Interventions for preventing oral candidiasis for patients with cancer receiving treatment 2007 · Cochrane All outcomes
  No trial reported this planned secondary outcome for any comparison in this review
  Studies not reported
  No studies found

Intervention not reported

• Oxygen for breathlessness in patients with chronic obstructive pulmonary disease who do not qualify for home oxygen… 2016 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 267 participants
  Low

ALK inhibitor vs any cytotoxic chemotherapy

ALK inhibitor leads to lower health‐related quality of life: time to deterioration in composite… compared with any cytotoxic chemotherapy (high certainty).

• Targeted therapy for advanced anaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer 2022 · Cochrane Headline outcomes only
  HR 0.52 [0.44, 0.6]
  5 studies · 1504 participants
  High

Intervention not reported

• Chimeric antigen receptor (CAR) T‐cell therapy for people with relapsed or refractory diffuse large B‐cell lymphoma 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 294 participants
  Very low

Exercise vs no exercise

• Exercise interventions for adults with cancer receiving radiation therapy alone 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 112 participants
  Low

Acupuncture vs psychological therapy

The review found no eligible studies for this question.

• Acupuncture for depression 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• First‐line therapy for adults with advanced renal cell carcinoma: a systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found