Cochrane · systematic review · CD013365
Chimeric antigen receptor (CAR) T‐cell therapy for people with relapsed or refractory diffuse large B‐cell lymphoma
Ernst, M, Oeser, A, Besiroglu, B, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings for the efficacy and safety of CAR T‐cell therapy for people with relapsed or refractory DLBCL
Population: people with relapsed or refractory DLBCL
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival ( | no estimate extracted | 8 studies · 567 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Quality of life ( | no estimate extracted | 2 studies · 294 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Any adverse events ( | no estimate extracted | 5 studies · 550 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Any serious adverse events ( | no estimate extracted | 4 studies · 281 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Cytokine release syndrome ( | no estimate extracted | 11 studies · 675 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Progression‐free survival ( | no estimate extracted | 9 studies · 575 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Complete response ( | no estimate extracted | 13 studies · 620 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |