Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

585 questions · 600 findings · 259 reviews

No studies found 323 · 53.8%GRADE not reported 46 · 7.7%Very low 94 · 15.7%Low 85 · 14.2%Moderate 42 · 7%High 10 · 1.7%

Antidepressants vs placebo

Quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0 indicates perfect health) between 0 and 14 weeks · predominantly knee osteoarthritis

Antidepressant probably leads to higher quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0… compared with placebo (moderate certainty).

1 finding from 1 review