Findings

What do systematic reviews say?

12 questions · 12 findings · 7 reviews · Headline outcomes only

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No studies found 4 · 33.3%GRADE not reported 0 · 0%Very low 1 · 8.3%Low 3 · 25%Moderate 4 · 33.3%High 0 · 0%

Extended‐field radiotherapy vs pelvic radiotherapy

Progression‐free survival

Extended‐field radiotherapy showed no clear difference in progression‐free survival compared with pelvic radiotherapy (moderate certainty).

1 finding from 1 review

Extended‐field radiotherapy for locally advanced cervical cancer 2018 · Cochrane Headline outcomes only
HR 0.92 [0.69, 1.22]
1 study · 377 participants
Moderate

Extended‐field radiotherapy vs pelvic chemoradiotherapy

Progression‐free survival

Extended‐field radiotherapy probably leads to lower progression‐free survival compared with pelvic chemoradiotherapy (moderate certainty).

1 finding from 1 review

Extended‐field radiotherapy for locally advanced cervical cancer 2018 · Cochrane Headline outcomes only
HR 0.52 [0.37, 0.72]
1 study · 389 participants
Moderate

Hypofractionated radiotherapy vs radiotherapy

Progression‐free survival · children and young adults with diffuse brainstem glioma

Hypofractionated radiotherapy showed no clear difference in progression‐free survival compared with conventional radiotherapy (low certainty).

1 finding from 1 review

Radiotherapy for diffuse brainstem glioma in children and young adults 2016 · Cochrane Headline outcomes only
HR 1.19 [0.63, 2.22]
1 study · 71 participants
Low

Hyperfractionated radiotherapy vs radiotherapy

Progression‐free survival · children and young adults with diffuse brainstem glioma

The review found no eligible studies for this question.

1 finding from 1 review

Radiotherapy for diffuse brainstem glioma in children and young adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Extended‐field chemoradiotherapy vs pelvic chemoradiotherapy

Progression‐free survival

It is very uncertain whether extended‐field chemoradiotherapy changes progression‐free survival compared with pelvic chemoradiotherapy (very low certainty).

1 finding from 1 review

Extended‐field radiotherapy for locally advanced cervical cancer 2018 · Cochrane Headline outcomes only
HR 0.25 [0.07, 0.87]
1 study · 74 participants
Very low

Concomitant (concurrent) chemoradiotherapy vs radical surgery

Progression‐free survival (PSF) · women (18 years and older) diagnosed with stage IB2 cervical cancer

The review found no eligible studies for this question.

1 finding from 1 review

Type II or type III radical hysterectomy compared to chemoradiotherapy as a primary intervention for stage IB2… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hysterectomy (simple or radical) with radiotherapy vs Radiotherapy alone

Progression‐free survival (PSF) · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with radiotherapy showed no clear difference in progression‐free survival Median compared with radiotherapy alone (low certainty).

1 finding from 1 review

Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
HR 0.77 [0.54, 1.1]
1 study · 256 participants
Low

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery plus WBRT

Progression‐free survival · people with single or solitary brain metastasis

Surgery plus whole brain radiotherapy (WBRT) showed no clear difference in progression‐free survival compared with stereotactic radiosurgery plus WBRT (low certainty).

1 finding from 1 review

Surgery versus stereotactic radiotherapy for people with single or solitary brain metastasis 2018 · Cochrane Headline outcomes only
RR 0.55 [0.22, 1.38]
1 study · 21 participants
Low

Surgery plus whole brain radiotherapy (WBRT) vs stereotactic radiosurgery

Progression‐free survival ‐ not measured · people with single or solitary brain metastasis

The review found no eligible studies for this question.

1 finding from 1 review

Surgery versus stereotactic radiotherapy for people with single or solitary brain metastasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Progression‐free survival · stages I to III NSCLC patients treated with surgery or radiotherapy with curative intent

The intervention showed no clear difference in progression‐free survival (moderate certainty).

1 finding from 1 review

Immunotherapy (excluding checkpoint inhibitors) for stage I to III non‐small cell lung cancer treated with surgery or… 2021 · Cochrane Headline outcomes only
HR 0.94 [0.86, 1.03]
5 studies · 3861 participants
Moderate

Minimally invasive surgery vs Standard therapy alone (radiotherapy or chemoradiotherapy)

Progression‐free survival · patients with small‐volume primary oropharyngeal carcinoma

The review found no eligible studies for this question.

1 finding from 1 review

Minimally invasive surgery versus radiotherapy/chemoradiotherapy for small‐volume primary oropharyngeal carcinoma 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hysterectomy (simple or radical) with neoadjuvant chemotherapy vs Radiotherapy alone

Disease or progression‐free survival Median · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with neoadjuvant chemotherapy showed no clear difference in disease‐ or progression‐free survival Median compared with radiotherapy alone (moderate certainty).

1 finding from 1 review

Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer 2022 · Cochrane Headline outcomes only
HR 0.75 [0.53, 1.05]
3 studies · 571 participants
Moderate