Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

268 questions · 274 findings · 96 reviews

No studies found 24 · 8.8%GRADE not reported 11 · 4%Very low 27 · 9.9%Low 66 · 24.1%Moderate 96 · 35%High 50 · 18.2%

Intervention not reported

Overall survival Hazard ratio · patients with resectable thoracic esophageal cancer

The intervention probably leads to lower overall survival Hazard ratio (moderate certainty).

1 finding from 1 review

Sodium thiosulfate vs no otoprotective intervention

Overall survival with intravenous platinum (i.e. mortality/number of participants deceased) · children with cancer treated with platinum‐based therapy

Sodium thiosulfate showed no clear difference in overall survival with intravenous platinum (i.e. mortality/number of… compared with no otoprotective intervention (low certainty).

1 finding from 1 review

Physical activity vs usual care

Overall survival (time interval between enrolment in the study and death of the person from any cause) · adults with non‐advanced colorectal cancer treated surgically or with neoadjuvant or adjuvant therapy, or both

The review found no eligible studies for this question.

1 finding from 1 review

Docetaxel vs non‐docetaxel‐containing regimens

Overall survival ‐ Substitutive comparisons · people with advanced gastric cancer

Docetaxel showed no clear difference in overall survival ‐ Substitutive comparisons compared with non‐docetaxel‐containing regimens (moderate certainty).

1 finding from 1 review

Carboplatin vs cisplatin chemotherapy

Overall survival (baseline risks for low‐ and high‐risk groups in the control arm were estimated at 1 year) · combination with third‐generation drugs for advanced non‐small cell lung cancer

Carboplatin showed no clear difference in overall survival (baseline risks for low‐ and high‐risk groups in… compared with cisplatin chemotherapy (high certainty).

1 finding from 1 review