Cochrane · systematic review · CD001556
Preoperative chemotherapy for resectable thoracic esophageal cancer
Kidane, B, Coughlin, S, Vogt, K, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 6 · 85.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Preoperative chemotherapy for resectable thoracic esophageal cancer
Population: patients with resectable thoracic esophageal cancer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival Hazard ratio | HR 0.88 [0.8, 0.96] | 10 studies · 2122 participants | Moderate Downgraded: risk of bias, imprecision |
Complete resection (R0) Histology | RR 1.11 [1.03, 1.19] | 9 studies · 2135 participants | Moderate Downgraded: risk of bias |
Local‐regional recurrence Radiology | RR 0.86 [0.63, 1.17] | 8 studies · 2047 participants | Moderate Downgraded: risk of bias |
Distant recurrence Radiology | RR 0.94 [0.78, 1.13] | 7 studies · 1947 participants | Moderate Downgraded: risk of bias |
Any complication Clinical | RR 0.93 [0.81, 1.08] | 5 studies · 1340 participants | Moderate Downgraded: risk of bias |
Postoperative death Clinical | RR 0.93 [0.68, 1.28] | 10 studies · 2196 participants | Low Downgraded: risk of bias, imprecision |
Anastomotic leaks Clinical/radiology | RR 0.92 [0.62, 1.37] | 8 studies · 1501 participants | Moderate Downgraded: risk of bias |