Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

15 questions · 17 findings · 3 reviews · Breast Cancer

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 11.8%Low 2 · 11.8%Moderate 2 · 11.8%High 11 · 64.7%

Intervention not reported

Breast cancer stage at the time of presentation: defined as the proportion of women with breast cancer diagnosed at early stage (stage 0, I, II) Time of outcome assessment: 3 years to 20 years Method of measurement: CBE · health workers

The intervention may leads to higher breast cancer stage at the time of presentation: defined as the… (low certainty).

1 finding from 1 review

Platinum‐containing chemotherapy vs chemotherapy without platinum

Disease-free survival · neoadjuvant therapy for early triple‐negative breast cancer

Platinum‐containing chemotherapy leads to lower DFS at 2 years compared with chemotherapy without platinum (high certainty).

2 findings from 1 review

Platinum‐containing chemotherapy vs chemotherapy without platinum

Disease-free survival · early triple‐negative breast cancer

Platinum‐containing chemotherapy leads to lower DFS at 2 years compared with chemotherapy without platinum (high certainty).

2 findings from 1 review

Hypofractionated radiation therapy vs conventionally fractionated radiation therapy

Mortality at 10 years · women treated with breast conserving therapy for early breast cancer

Hypofractionated radiation therapy showed no clear difference in mortality at 10 years compared with conventionally fractionated radiation therapy (high certainty).

1 finding from 1 review

Hypofractionated radiation therapy vs conventionally fractionated radiation therapy

Proportion of participants with relapse‐free survival at ≥ 12 months · women treated with breast conserving therapy for early breast cancer

Hypofractionated radiation therapy showed no clear difference in relapse‐free survival (RFS) at 10 years compared with conventionally fractionated radiation therapy (moderate certainty).

1 finding from 1 review

Hypofractionated radiation therapy vs conventionally fractionated radiation therapy

Local recurrence‐free survival · women treated with breast conserving therapy for early breast cancer

Hypofractionated radiation therapy showed no clear difference in local recurrence‐free survival (LR‐FS) at 10 years compared with conventionally fractionated radiation therapy (high certainty).

1 finding from 1 review

Hypofractionated radiation therapy vs conventionally fractionated radiation therapy

Breast cancer‐specific survival · women treated with breast conserving therapy for early breast cancer

Hypofractionated radiation therapy showed no clear difference in breast cancer‐specific survival (BC‐SS) at 10 years compared with conventionally fractionated radiation therapy (high certainty).

1 finding from 1 review

Intervention not reported

Breast cancer stage at the time of presentation: defined as the proportion of women with breast cancer diagnosed at late stage (stage III, IV) Time of outcome assessment: 3 years to 20 years Method of measurement: CBE · health workers

The intervention may leads to lower breast cancer stage at the time of presentation: defined as the… (low certainty).

1 finding from 1 review

Intervention not reported

Breast cancer mortality: defined as deaths among women who received a diagnosis of breast cancer Time of outcome assessment: 3 years to 20 years Method of measurement: death registration offices, hospital records, and house visits · health workers

It is very uncertain whether the intervention changes breast cancer mortality: defined as deaths among women who received… (very low certainty).

1 finding from 1 review