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Evidence found and GRADE certainty

33 questions · 34 findings · 5 reviews

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No studies found 12 · 35.3%GRADE not reported 5 · 14.7%Very low 1 · 2.9%Low 7 · 20.6%Moderate 9 · 26.5%High 0 · 0%

Comparison 1: route of antibiotic vs usual care

Neonatal mortality ‐ injectable antibiotic · neonates with sepsis

Comparison 1: route of antibiotic probably leads to lower neonatal mortality ‐ injectable antibiotic compared with standard care (moderate certainty).

1 finding from 1 review

Comparison 1: route of antibiotic vs usual care

Neonatal mortality ‐ oral + injectable antibiotics · neonates with sepsis

Comparison 1: route of antibiotic showed no clear difference in neonatal mortality ‐ oral + injectable antibiotics compared with standard care (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Mortality and morbidity prior to discharge (Neonatal intensive care admissions) · Women with meconium‐stained amniotic fluid in labour, gestational age more than 24 weeks

Antibiotic showed no clear difference in mortality and morbidity prior to discharge (Neonatal intensive care… compared with placebo (low certainty).

1 finding from 1 review

Comparison 1: antibiotic alone or antibiotic with other newborn care interventions vs usual care

Neonatal mortality · neonates with sepsis

Comparison 1: antibiotic alone or antibiotic with other newborn care… showed no clear difference in neonatal mortality ‐ antibiotics alone compared with standard care (moderate certainty).

2 findings from 1 review

Comparison 2: any simplified antibiotic regimen vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: any simplified antibiotic regimen showed no clear difference in neonatal mortality compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).

1 finding from 1 review

Comparison 1: community‐based antibiotic delivery vs usual care

Late neonatal mortality · neonates with sepsis

Comparison 1: community‐based antibiotic delivery probably leads to lower late neonatal mortality compared with standard care (moderate certainty).

1 finding from 1 review

Comparison 1: community‐based antibiotic delivery vs usual care

Early neonatal mortality · neonates with sepsis

Comparison 1: community‐based antibiotic delivery probably leads to lower early neonatal mortality compared with standard care (moderate certainty).

1 finding from 1 review

Comparison 1: referral or full course of antibiotics vs usual care

Neonatal mortality ‐ full course · neonates with sepsis

It is very uncertain whether comparison 1: referral or full course of antibiotics changes neonatal mortality ‐ full course compared with standard care (very low certainty).

1 finding from 1 review

Comparison 1: referral or full course of antibiotics vs usual care

Neonatal mortality ‐ first dose and referral · neonates with sepsis

Comparison 1: referral or full course of antibiotics may leads to lower neonatal mortality ‐ first dose and referral compared with standard care (low certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 7 days oral amoxicillin + injectable gentamicin showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 2 days injectable benzylpenicillin + injectable… showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (low certainty).

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 2 days oral amoxicillin + injectable gentamicin… showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with fast breathing alone

Comparison 2: 7 days oral amoxicillin showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (low certainty).

1 finding from 1 review