Findings

What do systematic reviews say?

6 questions · 6 findings · 5 reviews

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No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 2 · 33.3%Low 2 · 33.3%Moderate 1 · 16.7%High 0 · 0%

Half strength formula vs full strength formula

Necrotising enterocolitis · exclusively formula‐fed preterm or low birth weight infants

The review found no eligible studies for this question.

1 finding from 1 review

Dilute versus full‐strength formula in exclusively formula‐fed preterm or low birth weight infants 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Formula vs donor breast milk

Necrotising enterocolitis · preterm or low birth weight infants

Formula probably leads to higher necrotising enterocolitis compared with donor breast milk (moderate certainty).

1 finding from 1 review

Formula versus donor breast milk for feeding preterm or low birth weight infants 2019 · Cochrane Headline outcomes only
RR 1.87 [1.23, 2.85]
9 studies · 1675 participants
Moderate

Hydrolysed vs non‐hydrolysed formula

Necrotising enterocolitis · feeding preterm infants

Hydrolysed showed no clear difference in necrotising enterocolitis compared with non‐hydrolysed formula (low certainty).

1 finding from 1 review

Protein hydrolysate versus standard formula for preterm infants 2019 · Cochrane Headline outcomes only
RR 1.1 [0.36, 3.34]
5 studies · 385 participants
Low

High vs standard volume of unfortified human milk or term formula

Necrotising enterocolitis · preterm or low birth weight infants

It is very uncertain whether high changes necrotising enterocolitis compared with standard volume of unfortified human milk or term formula (very low certainty).

1 finding from 1 review

High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants 2021 · Cochrane Headline outcomes only
RR 1.03 [0.07, 15.78]
1 study · 61 participants
Very low

High vs standard volume of fortified human milk or preterm formula

Necrotising enterocolitis · preterm or low birth weight infants

It is very uncertain whether high changes necrotising enterocolitis compared with standard volume of fortified human milk or preterm formula (very low certainty).

1 finding from 1 review

High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants 2021 · Cochrane Headline outcomes only
RR 0.74 [0.12, 4.51]
2 studies · 283 participants
Very low

Intervention not reported

Necrotising enterocolitis · preterm infants

The intervention showed no clear difference in necrotising enterocolitis (low certainty).

1 finding from 1 review

Nutrient‐enriched formula versus standard formula for preterm infants 2019 · Cochrane Headline outcomes only
RR 0.72 [0.41, 1.25]
3 studies · 489 participants
Low