Cochrane · systematic review · CD004204

Nutrient‐enriched formula versus standard formula for preterm infants

Walsh, V, Brown, JVE, Askie, LM, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library

NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 83.3%Moderate 1 · 16.7%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Nutrient‐enriched formula for preterm infants

Population: preterm infants
6 questions
OutcomeEffectEvidenceStatus / GRADE
Weight gain (g/kg/d)
no estimate extracted6 studies · 440 participantsLow
Downgraded: risk of bias
Length gain (mm/week)
no estimate extracted5 studies · 386 participantsLow
Downgraded: risk of bias
Head circumference gain (mm/week)
no estimate extracted5 studies · 399 participantsLow
Downgraded: risk of bias
Mental Development Index (MDI) at 18 months
no estimate extracted2 studies · 310 participantsModerate
Downgraded: risk of bias
Psychomotor Development Index (PDI) at 18 months
no estimate extracted2 studies · 310 participantsLow
Downgraded: risk of bias
Necrotising enterocolitis
RR 0.72 [0.41, 1.25]3 studies · 489 participantsLow
Downgraded: risk of bias