Findings

What do systematic reviews say?

6 questions · 6 findings · 5 reviews · Neonatal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 50%Low 2 · 33.3%Moderate 1 · 16.7%High 0 · 0%

Early full enteral feeding vs delayed or progressive feeding

Necrotising enterocolitis · preterm or low birth weight infants

It is very uncertain whether early full enteral feeding changes necrotising enterocolitis compared with delayed or progressive feeding (very low certainty).

1 finding from 1 review

Early full enteral feeding for preterm or low birth weight infants 2020 · Cochrane Headline outcomes only
RR 0.98 [0.38, 2.54]
6 studies · 522 participants
Very low

Enteral zinc supplementation vs no zinc supplementation

Necrotising enterocolitis · preterm infants

Enteral zinc supplementation showed no clear difference in necrotising enterocolitis compared with no zinc supplementation (low certainty).

1 finding from 1 review

Enteral zinc supplementation for prevention of morbidity and mortality in preterm neonates 2021 · Cochrane Headline outcomes only
RR 0.08 [0, 1.33]
1 study · 193 participants
Low

Slow vs faster rates of enteral feed advancement

Necrotising enterocolitis · very preterm or very low birth weight infants

Slow showed no clear difference in necrotising enterocolitis before hospital discharge compared with faster rates of enteral feed advancement (moderate certainty).

1 finding from 1 review

Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants 2021 · Cochrane Headline outcomes only
RR 1.06 [0.83, 1.37]
14 studies · 4026 participants
Moderate

High vs standard volume of unfortified human milk or term formula

Necrotising enterocolitis · preterm or low birth weight infants

It is very uncertain whether high changes necrotising enterocolitis compared with standard volume of unfortified human milk or term formula (very low certainty).

1 finding from 1 review

High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants 2021 · Cochrane Headline outcomes only
RR 1.03 [0.07, 15.78]
1 study · 61 participants
Very low

High vs standard volume of fortified human milk or preterm formula

Necrotising enterocolitis · preterm or low birth weight infants

It is very uncertain whether high changes necrotising enterocolitis compared with standard volume of fortified human milk or preterm formula (very low certainty).

1 finding from 1 review

High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants 2021 · Cochrane Headline outcomes only
RR 0.74 [0.12, 4.51]
2 studies · 283 participants
Very low

Intervention not reported

Necrotising enterocolitis prior to hospital discharge · very preterm (< 32 weeks' gestation) or very low birth weight (< 1500 g) infants

The intervention may leads to lower necrotising enterocolitis prior to hospital discharge (low certainty).

1 finding from 1 review

Delayed introduction of progressive enteral feeds to prevent necrotising enterocolitis in very low birth weight infants 2022 · Cochrane Headline outcomes only
RR 0.81
13 studies · 1507 participants
Low