Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

89 questions · 89 findings · 26 reviews · Headline outcomes only

No studies found 19 · 21.3%GRADE not reported 0 · 0%Very low 20 · 22.5%Low 25 · 28.1%Moderate 17 · 19.1%High 8 · 9%

Summary of findings table ‐ Quality and volume of gastric residual vs quality of gastric residual alone

Mortality before hospital discharge · feed interruption while monitoring gastric residual

Summary of findings table ‐ Quality and volume of gastric residual showed no clear difference in all‐cause mortality before hospital discharge compared with quality of gastric residual alone (low certainty).

1 finding from 1 review

Targeted individualized vs standard non‐individualized fortification

In‐hospital mortality · promoting growth and development in very low birth weight infants receiving human milk

It is very uncertain whether targeted individualized changes in‐hospital mortality compared with standard non‐individualized fortification (very low certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

Infant Mortality at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV dual regimen administered to infants for 14… showed no clear difference in infant Mortality at 24 months among those uninfected at birth compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

Infant Mortality at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV dual regimen administered to infants for 14… showed no clear difference in infant Mortality at 9 months among those whose HIV diagnostic… compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

More frequent (less than eight hours) vs less frequent (eight hours or greater) monitoring of gastric residual volume

Mortality (at the end of · adults receiving EN via nasogastric or gastrostomy tube

It is very uncertain whether more frequent (less than eight hours) changes mortality (at the end of compared with less frequent (eight hours or greater) monitoring of gastric… (very low certainty).

1 finding from 1 review

No monitoring vs frequent monitoring (12 hours or less) of gastric residual volume

Mortality (at the end of · adults receiving EN via nasogastric or gastrostomy tube

It is very uncertain whether no monitoring changes mortality (at the end of compared with frequent monitoring (12 hours or less) of gastric residual volume (very low certainty).

1 finding from 1 review