Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

141 questions · 143 findings · 48 reviews

No studies found 25 · 17.5%GRADE not reported 9 · 6.3%Very low 36 · 25.2%Low 35 · 24.5%Moderate 31 · 21.7%High 7 · 4.9%

Meropenem vs usual care

All‐cause mortality maximum · newborns with late‐onset sepsis

It is very uncertain whether meropenem changes all‐cause mortality maximum compared with standard care (very low certainty).

1 finding from 1 review

Intervention not reported

Meningitis‐related mortality · patients with a recent BSF independent of the presence or severity of CSF leakage

The intervention showed no clear difference in meningitis‐related mortality (moderate certainty).

1 finding from 1 review

Azithromycin vs placebo or usual care

All‐cause mortality at day 28 · people with moderate to severe disease (WHO scale 4–9); all studies contributing results to the summary of findings table included people…

Azithromycin showed no clear difference in all‐cause mortality at day 28 compared with placebo or standard of care alone (high certainty).

1 finding from 1 review

Azithromycin vs placebo or usual care

All‐cause mortality at day 28 · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

Azithromycin showed no clear difference in all‐cause mortality at day 28 compared with placebo or standard of care alone (low certainty).

1 finding from 1 review

Intervention not reported

Mortality Clinical assessment · newborn infants who require a central venous catheter

It is very uncertain whether the intervention changes mortality Clinical assessment (very low certainty).

1 finding from 1 review

Intervention not reported

Secondary ‐ All‐cause mortality · Patients with acute uncomplicated diverticulitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Secondary ‐ All cause mortality · Patients with acute uncomplicated diverticulitis

The review found no eligible studies for this question.

1 finding from 1 review