Cochrane · systematic review · CD013837
Antibiotic regimens for early‐onset neonatal sepsis
Korang, SK, Safi, S, Nava, C, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
NeonatalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 14 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ampicillin plus gentamicin compared with penicillin plus gentamicin for early‐onset neonatal sepsis
Population: neonates with early‐onset sepsis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality maximum Ampicillin plus gentamicin vs penicillin plus gentamicin | RR 0.56 [0.3, 1.06] | 1 study · 283 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Serious adverse events maximum Ampicillin plus gentamicin vs penicillin plus gentamicin | RR 0.93 [0.72, 1.21] | 1 study · 283 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Circulatory support maximum Ampicillin plus gentamicin vs penicillin plus gentamicin | RR 0.93 [0.72, 1.21] | 1 study · 283 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Neurological developmental impairment maximum Ampicillin plus gentamicin vs penicillin plus gentamicin | RR 0.81 [0.4, 1.61] | 1 study · 283 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Necrotising enterocolitis maximum Ampicillin plus gentamicin vs penicillin plus gentamicin | RR 1.24 [0.5, 3.05] | 1 study · 283 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Piperacillin plus tazobactam compared with amikacin for early‐onset neonatal sepsis
Population: neonates with early‐onset sepsis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality maximum Piperacillin plus tazobactam vs amikacin | RR 0.32 [0.01, 7.61] | 1 study · 59 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Serious adverse events maximum Piperacillin plus tazobactam vs amikacin | RR 0.97 [0.15, 6.41] | 1 study · 59 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Ticarcillin plus clavulanic acid compared with piperacillin plus gentamicin for early‐onset neonatal sepsis
Population: neonates with early‐onset sepsis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality maximum Ticarcillin plus clavulanic acid vs piperacillin plus gentamicin | RR 0.75 [0.19, 2.9] | 1 study · 72 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Serious adverse events maximum Ticarcillin plus clavulanic acid vs piperacillin plus gentamicin | RR 0.75 [0.19, 2.9] | 1 study · 72 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Piperacillin compared with ampicillin plus amikacin for early‐onset neonatal sepsis
Population: neonates with early‐onset sepsis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality maximum Piperacillin vs ampicillin plus amikacin | RR 0.62 [0.35, 1.1] | 1 study · 396 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Serious adverse events maximum Piperacillin vs ampicillin plus amikacin | RR 0.62 [0.35, 1.1] | 1 study · 396 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Nephrotoxicity maximum Piperacillin vs ampicillin plus amikacin | RR 1.14 [0.8, 1.61] | 1 study · 396 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Ceftazidime compared with benzylpenicillin plus gentamicin for early‐onset neonatal sepsis
Population: neonates with early‐onset sepsis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality maximum Ceftazidime vs benzylpenicillin plus gentamicin | no estimate extracted | 1 study · 55 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Serious adverse events maximum Ceftazidime vs benzylpenicillin plus gentamicin | no estimate extracted | 1 study · 55 participants | Very low Downgraded: risk of bias, imprecision, indirectness |