Cochrane · systematic review · CD004884
Antibiotic prophylaxis for preventing meningitis in patients with basilar skull fractures
Ratilal, BO, Costa, J, Pappamikail, L, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Acute Respiratory InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 3 · 60%High 1 · 20%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: patients with a recent BSF independent of the presence or severity of CSF leakage
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of meningitis | OR 0.69 [0.29, 1.61] | 4 studies · 208 participants | Moderate Downgraded: risk of bias, imprecision |
All‐cause mortality | OR 1.68 [0.41, 6.95] | 4 studies · 208 participants | Moderate Downgraded: risk of bias, imprecision |
Meningitis‐related mortality | OR 1.03 [0.14, 7.4] | 4 studies · 208 participants | Moderate Downgraded: risk of bias, imprecision |
Need for surgical correction in patients with CSF leakage | no estimate extracted | 1 study · 109 participants | Low Downgraded: risk of bias, imprecision |
Non‐CNS infection | OR 0.61 [0.15, 2.46] | 1 study · 52 participants | High |