Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

76 questions · 78 findings · 33 reviews

No studies found 9 · 11.5%GRADE not reported 5 · 6.4%Very low 20 · 25.6%Low 24 · 30.8%Moderate 14 · 17.9%High 6 · 7.7%

Azithromycin vs placebo or usual care

All‐cause mortality at day 28 · people with moderate to severe disease (WHO scale 4–9); all studies contributing results to the summary of findings table included people…

Azithromycin showed no clear difference in all‐cause mortality at day 28 compared with placebo or standard of care alone (high certainty).

1 finding from 1 review

Azithromycin vs placebo or usual care

All‐cause mortality at day 28 · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

Azithromycin showed no clear difference in all‐cause mortality at day 28 compared with placebo or standard of care alone (low certainty).

1 finding from 1 review

Intervention not reported

Secondary ‐ All‐cause mortality · Patients with acute uncomplicated diverticulitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Secondary ‐ All cause mortality · Patients with acute uncomplicated diverticulitis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Secondary ‐ All‐cause mortality  · Patients with acute uncomplicated diverticulitis

The intervention showed no clear difference in secondary ‐ All‐cause mortality  (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality in children with HIV infection ‐ isoniazid prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in mortality in children with HIV infection ‐ isoniazid prophylaxis only (low certainty).

1 finding from 1 review

Intervention not reported

Mortality in children with HIV infection ‐ co‐trimoxazole prophylaxis only · children with HIV infection aged 12 years and under

The intervention probably leads to lower mortality in children with HIV infection ‐ co‐trimoxazole… (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Mortality and morbidity prior to discharge (Neonatal intensive care admissions) · Women with meconium‐stained amniotic fluid in labour, gestational age more than 24 weeks

Antibiotic showed no clear difference in mortality and morbidity prior to discharge (Neonatal intensive care… compared with placebo (low certainty).

1 finding from 1 review