Findings

What do systematic reviews say?

108 questions · 115 findings · 61 reviews

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No studies found 22 · 19.1%GRADE not reported 4 · 3.5%Very low 23 · 20%Low 36 · 31.3%Moderate 21 · 18.3%High 9 · 7.8%

Time‐directed extubation protocol vs usual care

Mortality ‐ Death at any time after surgery · adult cardiac surgical patients

Time‐directed extubation protocol showed no clear difference in mortality ‐ Death at any time after surgery compared with usual care (low certainty).

1 finding from 1 review

Fast‐track cardiac care for adult cardiac surgical patients 2016 · Cochrane Headline outcomes only
OR 0.8 [0.45, 1.45]
10 studies · 1802 participants
Low

Mediterranean dietary intervention vs usual care

CVD mortality · adults with established cardiovascular disease

Mediterranean dietary intervention may leads to lower CVD mortality compared with usual care (low certainty).

1 finding from 1 review

Mediterranean‐style diet for the primary and secondary prevention of cardiovascular disease 2019 · Cochrane Headline outcomes only
RR 0.35 [0.15, 0.82]
1 study · 605 participants
Low

Daily sedation interruption vs usual care or protocolized sedation strategies that do not include daily sedation interruption

ICU mortality · Critically ill adults receiving mechanical ventilation in ICU

Daily sedation interruption showed no clear difference in ICU mortality compared with usual care or protocolized sedation strategies that do not include… (moderate certainty).

1 finding from 1 review

Daily sedation interruption versus no daily sedation interruption for critically ill adult patients requiring invasive… 2014 · Cochrane Headline outcomes only
RR 0.96 [0.77, 1.21]
7 studies · 815 participants
Moderate

LHWs vs usual care

Mortality among children less than 5 years Verbal autopsy · patients with reducing mortality and morbidity in children <5 years

LHWs showed no clear difference in mortality among children less than 5 years Verbal autopsy compared with usual care (low certainty).

1 finding from 1 review

Lay health workers in primary and community health care for maternal and child health and the management of infectious… 2010 · Cochrane Headline outcomes only
RR 0.75 [0.55, 1.03]
3 studies · 56378 participants
Low

General health checks vs usual care

Total mortality · Adults (general population)

General health checks showed no clear difference in total mortality compared with usual care (high certainty).

1 finding from 1 review

General health checks in adults for reducing morbidity and mortality from disease 2019 · Cochrane Headline outcomes only
RR 1 [0.97, 1.03]
11 studies · 233298 participants
High

Mediterranean dietary intervention vs usual care

Total mortality · adults with established cardiovascular disease

Mediterranean dietary intervention may leads to lower total mortality compared with usual care (low certainty).

1 finding from 1 review

Mediterranean‐style diet for the primary and secondary prevention of cardiovascular disease 2019 · Cochrane Headline outcomes only
RR 0.44 [0.21, 0.92]
1 study · 605 participants
Low

Internet‐based interventions vs usual care or no treatment

Total mortality · patients with coronary heart disease

Internet‐based interventions showed no clear difference in total mortality compared with usual care or no care (low certainty).

1 finding from 1 review

Internet‐based interventions for the secondary prevention of coronary heart disease 2015 · Cochrane Headline outcomes only
OR 0.27 [0.04, 1.63]
6 studies · 895 participants
Low

General health checks vs usual care

Mortality: all cancers · Adults (general population)

General health checks showed no clear difference in cancer mortality compared with usual care (high certainty).

1 finding from 1 review

General health checks in adults for reducing morbidity and mortality from disease 2019 · Cochrane Headline outcomes only
RR 1.01 [0.92, 1.12]
8 studies · 139290 participants
High

Self‐staffing vs usual staffing

Patient mortality · nurses working on acute care, intensive care or medical care units

The review found no eligible studies for this question.

1 finding from 1 review

Hospital nurse‐staffing models and patient‐ and staff‐related outcomes 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Corticosteroids vs placebo or usual care

Hospital mortality · children and adults with sepsis

Corticosteroids probably leads to lower hospital mortality compared with placebo or usual care (moderate certainty).

1 finding from 1 review

Corticosteroids for treating sepsis in children and adults 2019 · Cochrane Headline outcomes only
RR 0.9 [0.82, 0.99]
26 studies · 8183 participants
Moderate

Thromboelastography (TEG) or thromboelastometry (ROTEM) vs standard laboratory test (SLT)‐guided transfusion

All‐cause mortality · adults or children with bleeding

Thromboelastography (TEG) or thromboelastometry (ROTEM) may leads to lower mortality compared with standard laboratory test (SLT)‐guided transfusion (low certainty).

1 finding from 1 review

Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treatment versus usual care in adults… 2016 · Cochrane Headline outcomes only
RR 0.36 [0.16, 0.84]
4 studies · 272 participants
Low

Exercise‐based cardiac rehabilitation vs usual care

All‐cause mortality · adults with heart failure

Exercise‐based cardiac rehabilitation showed no clear difference in all‐cause mortality compared with usual care (low certainty).

1 finding from 1 review

Exercise‐based cardiac rehabilitation for adults with heart failure 2024 · Cochrane Headline outcomes only
RR 0.93 [0.71, 1.21]
34 studies · 3941 participants
Low

Telemedicine vs usual care

All‐cause mortality

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for people with type 2 diabetes mellitus fasting during Ramadan 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Patient education vs usual care

All‐cause mortality

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for people with type 2 diabetes mellitus fasting during Ramadan 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Drug dosage reduction vs usual care

All‐cause mortality

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for people with type 2 diabetes mellitus fasting during Ramadan 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin A vs placebo or usual care

All‐cause mortality · children aged between 6 months and 5 years

Vitamin A supplementation leads to lower all‐cause mortality compared with placebo or usual care (high certainty).

1 finding from 1 review

Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age 2022 · Cochrane Headline outcomes only
RR 0.88 [0.83, 0.93]
19 studies · 1202382 participants
High

Ultrafiltration (UF) vs usual care

All‐cause mortality · people with AHF

It is very uncertain whether ultrafiltration (UF) changes all‐cause mortality compared with usual care (UC) (very low certainty).

1 finding from 1 review

Ultrafiltration for acute heart failure 2022 · Cochrane Headline outcomes only
RR 0.61 [0.13, 2.85]
3 studies · 286 participants
Very low

Casirivimab/imdevimab vs usual care

Mortality by day 30 · hospitalised individuals with COVID‐19 (moderate to severe disease)

Casirivimab/imdevimab showed no clear difference in mortality by day 30 compared with usual care alone (moderate certainty).

1 finding from 1 review

SARS‐CoV‐2‐neutralising monoclonal antibodies for treatment of COVID‐19 2021 · Cochrane Headline outcomes only
RR 0.94 [0.87, 1.02]
1 study · 9785 participants
Moderate

Casirivimab/imdevimab vs usual care

Mortality by day 60 · hospitalised individuals with COVID‐19 (moderate to severe disease)

The review found no eligible studies for this question.

1 finding from 1 review

SARS‐CoV‐2‐neutralising monoclonal antibodies for treatment of COVID‐19 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Technique of BP measurement: CRADLE intervention vs usual care

Perinatal mortality · pregnant women, or those within 42 days of delivery

The review found no eligible studies for this question.

1 finding from 1 review

Setting and techniques for monitoring blood pressure during pregnancy 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found