Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

187 questions · 189 findings · 84 reviews

No studies found 16 · 8.5%GRADE not reported 7 · 3.7%Very low 44 · 23.3%Low 57 · 30.2%Moderate 47 · 24.9%High 18 · 9.5%

Angiotensin receptor neprilysin inhibitors (ARNIs) vs usual care

All‐cause mortality (RR) Range of · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor neprilysin inhibitors (ARNIs) leads to lower all‐cause mortality (RR) Range of compared with usual care (high certainty).

1 finding from 1 review

Angiotensin receptor neprilysin inhibitors (ARNIs) vs usual care

Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor neprilysin inhibitors (ARNIs) showed no clear difference in cardiovascular mortality (RR) Median compared with usual care (moderate certainty).

1 finding from 1 review

Extensive tests vs tests at the physician's discretion

Cancer‐related mortality at maximal · people with unprovoked VTE

Extensive tests showed no clear difference in cancer‐related mortality2 compared with tests at the physician's discretion (low certainty).

1 finding from 1 review

Intensity of glycaemic control for women with gestational diabetes mellitus ‐ strict glycaemic targets vs less‐tight glycaemic targets (child (as neonate, child, adult) outcomes)

Death or serious morbidity composite · Children (as neonate, child, adult) of women with GDM

Intensity of glycaemic control for women with gestational diabetes… showed no clear difference in composite of mortality or serious morbidity (as defined by trial) compared with less‐tight glycaemic targets (child (as neonate, child, adult)… (low certainty).

1 finding from 1 review

Intermittent ausculation of fetal heart rate in labour for fetal well‐being ‐ Intensive Pinard vs routine Pinard (outcomes

Perinatal mortality · women in established labour and their babies.

It is very uncertain whether intermittent ausculation of fetal heart rate in labour for fetal… changes perinatal mortality compared with routine Pinard (outcomes (very low certainty).

1 finding from 1 review

Dopamine‐milrinone vs dopamine‐dobutamine

All‐cause short‐term mortality: at intensive care unit · adults with cardiogenic shock

It is very uncertain whether dopamine‐milrinone changes all‐cause short‐term mortality: at intensive care unit compared with dopamine‐dobutamine (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Mortality and morbidity prior to discharge (Neonatal intensive care admissions) · Women with meconium‐stained amniotic fluid in labour, gestational age more than 24 weeks

Antibiotic showed no clear difference in mortality and morbidity prior to discharge (Neonatal intensive care… compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Mortality · Adults (>18 years) with pulmonary hypertension of varied aetiology (PAH, CTEPH and left heart disease)

The intervention showed no clear difference in mortality (low certainty).

1 finding from 1 review

Aspirin vs placebo

Total mortality · adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary hypertension were…

Aspirin showed no clear difference in total mortality compared with placebo (low certainty).

1 finding from 1 review