Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

31 questions · 31 findings · 19 reviews

No studies found 3 · 9.7%GRADE not reported 0 · 0%Very low 6 · 19.4%Low 10 · 32.3%Moderate 9 · 29%High 3 · 9.7%

Non‐invasive ventilation vs supplemental oxygen or no treatment

All‐cause mortality · patients with the management of transient tachypnea of the newborn

It is very uncertain whether non‐invasive respiratory support changes all‐cause mortality compared with supplemental oxygen or no treatment (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

All‐cause mortality WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in all‐cause mortality WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality at longest · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…

It is very uncertain whether the intervention changes mortality at longest (very low certainty).

1 finding from 1 review

Intervention not reported

Mortality within the longest · surgical patients with need for abdominal, caesarean section, orthopaedic or breast surgery

The intervention showed no clear difference in mortality within the longest (low certainty).

1 finding from 1 review

Intervention not reported

Mortality within the longest · surgical patients with need for abdominal, caesarean section, orthopaedic or breast surgery

It is very uncertain whether the intervention changes mortality within the longest (very low certainty).

1 finding from 1 review

HFNC vs standard oxygen therapy

In‐hospital mortality (up to 90 days; included studies reported in‐hospital mortality, and mortality up to 28 days and up to ICU discharge) · adults in the ICU, requiring respiratory support

HFNC showed no clear difference in in‐hospital mortality (up to 90 days; included studies reported… compared with standard oxygen therapy (moderate certainty).

1 finding from 1 review

Intervention not reported

Death at any time in trial period case mortality count · Patients with acute traumatic brain injury

The intervention probably leads to lower death at any time in trial period case mortality count (moderate certainty).

1 finding from 1 review