Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

398 questions · 434 findings · 166 reviews

No studies found 95 · 21.9%GRADE not reported 31 · 7.1%Very low 91 · 21%Low 110 · 25.3%Moderate 78 · 18%High 29 · 6.7%

Pancreaticojejunostomy vs pancreatogastrostomy after pancreatoduodectomy

Postoperative mortality · adults undergoing pancreatoduodenectomy (mainly for pancreatic cancer)

Pancreaticojejunostomy showed no clear difference in postoperative mortality compared with pancreatogastrostomy after pancreatoduodectomy (moderate certainty).

1 finding from 1 review

Comparison 1: community‐based antibiotic delivery vs usual care

Early neonatal mortality · neonates with sepsis

Comparison 1: community‐based antibiotic delivery probably leads to lower early neonatal mortality compared with standard care (moderate certainty).

1 finding from 1 review

Community health educational interventions vs control

Early neonatal mortality · developing countries

It is very uncertain whether community health educational interventions changes early neonatal mortality compared with control (very low certainty).

2 findings from 1 review

Lipopeptide antibiotic (daptomycin) vs aminoglycoside (low‐dose gentamicin) plus anti‐staphylococcal penicillin (nafcillin, oxacillin or flucloxacillin) or glycopeptide antibiotic (vancomycin)

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with endocarditis caused by Staphylococcus aureus

The review found no eligible studies for this question.

1 finding from 1 review

Highest vs lowest selenium exposure

Mortality: all cancers · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes cancer mortality risk No. of participants: 183,863 (7 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Comparison 1: community‐based antibiotic delivery vs usual care

Sepsis‐specific mortality · neonates with sepsis

Comparison 1: community‐based antibiotic delivery showed no clear difference in sepsis‐specific mortality compared with standard care (low certainty).

1 finding from 1 review

Higher vs lower omega‐6: additional key outcomes

All‐cause mortality Study duration range 12‐96 months Omega‐6 dose range 1.5%‐24.5% E · adults with or without existing CVD

Higher showed no clear difference in all‐cause mortality Study duration range 12‐96 months Omega‐6 dose… compared with lower omega‐6: primary outcomes (low certainty).

1 finding from 1 review

Higher vs lower omega‐6: additional key outcomes

Cardiovascular mortality · adults with or without existing CVD

It is very uncertain whether higher changes cardiovascular mortality Study duration range 24‐96 months Omega‐6… compared with lower omega‐6: primary outcomes (very low certainty).

1 finding from 1 review