Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

64 questions · 66 findings · 39 reviews

No studies found 7 · 10.6%GRADE not reported 5 · 7.6%Very low 19 · 28.8%Low 20 · 30.3%Moderate 14 · 21.2%High 1 · 1.5%

Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA

Mortality (all‐cause) · patients with chronic obstructive pulmonary disease

It is very uncertain whether once‐daily ICS/LABA combined inhalers changes mortality (all‐cause) compared with once‐daily LAMA (very low certainty).

1 finding from 1 review

Tiotropium + LABA/ICS combination vs tiotropium

Mortality (all‐cause) · patients with chronic obstructive pulmonary disease

Tiotropium + LABA/ICS combination showed no clear difference in mortality (all‐cause) compared with tiotropium (moderate certainty).

1 finding from 1 review

Tiotropium vs ipratropium

Mortality (all‐cause) · chronic obstructive pulmonary disease (COPD). Participants in included studies had an average baseline FEV1 of around 40% predicted and…

Tiotropium showed no clear difference in mortality (all‐cause) compared with ipratropium (moderate certainty).

1 finding from 1 review

Tiotropium vs long‐acting beta‐agonists

Mortality (all‐cause) · patients with stable chronic obstructive pulmonary disease and > 10 pack years smoking history

It is very uncertain whether tiotropium changes mortality (all‐cause) compared with long‐acting beta‐agonists (very low certainty).

1 finding from 1 review

Multi‐component interventions (with telehealth as a component of care) vs usual care

Anti‐cytokine, all‐cause mortality ‐ uncertain risk of bias · patients with chronic obstructive pulmonary disease

It is very uncertain whether multi‐component interventions (with telehealth as a component of care) changes mortality (all‐cause) overall analysis compared with usual care (very low certainty).

1 finding from 1 review

Systematic screening vs no/opportunistic screening

All‐cause mortality · general population including those at moderate to high risk of CVD, mean age between 30 and 75

Systematic screening showed no clear difference in all‐cause mortality compared with no/opportunistic screening (low certainty).

1 finding from 1 review