Findings

What do systematic reviews say?

7 questions · 7 findings · 6 reviews · Gynaecology and Fertility

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 71.4%Moderate 1 · 14.3%High 1 · 14.3%

Low‐dose aspirin vs placebo or no treatment

Miscarriage · women with subfertility

Low‐dose aspirin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).

1 finding from 1 review

Aspirin for in vitro fertilisation 2016 · Cochrane Headline outcomes only
RR 1.1 [0.68, 1.77]
5 studies · 1497 participants
Low

Embryo culture with low oxygen concentration vs embryo culture with atmospheric oxygen concentration

Miscarriage · patients with miscarriage rate

Embryo culture with low oxygen concentration showed no clear difference in miscarriage rate compared with embryo culture with atmospheric oxygen concentration (low certainty).

1 finding from 1 review

Low oxygen concentrations for embryo culture in assisted reproductive technologies 2012 · Cochrane Headline outcomes only
OR 1.28 [0.86, 1.9]
3 studies · 1291 participants
Low

Repeated single embryo transfer (mixed policies) vs multiple embryo transfer

Miscarriage · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Repeated single embryo transfer (mixed policies) showed no clear difference in miscarriage rate compared with multiple embryo transfer (low certainty).

1 finding from 1 review

Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
odds ratio 2.14 [0.93, 4.95]
2 studies · 282 participants
Low

Single vs multiple embryo transfer

Miscarriage · transfer following in vitro fertilisation or intracytoplasmic sperm injection

Single showed no clear difference in miscarriage rate compared with multiple embryo transfer (low certainty).

1 finding from 1 review

Number of embryos for transfer following in vitro fertilisation or intra‐cytoplasmic sperm injection 2020 · Cochrane Headline outcomes only
odds ratio 0.96 [0.66, 1.42]
7 studies · 1560 participants
Low

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Miscarriage · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

Day 3 showed no clear difference in miscarriage rate per woman compared with day 2 embryo transfer following IVF or ICSI (moderate certainty).

1 finding from 1 review

Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection 2016 · Cochrane Headline outcomes only
RR 1.16 [0.84, 1.6]
9 studies · 2153 participants
Moderate

High vs low or no hyaluronic acid

Miscarriage · couples undergoing embryo transfer

High showed no clear difference in miscarriage rate compared with low or no hyaluronic acid (low certainty).

1 finding from 1 review

Hyaluronic acid in embryo transfer media for assisted reproductive technologies 2020 · Cochrane Headline outcomes only
RR 0.82 [0.67, 1]
7 studies · 3091 participants
Low

Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse

Miscarriage · infertile women with polycystic ovary syndrome

Letrozole with or without adjuncts showed no clear difference in miscarriage rate per pregnancy compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).

1 finding from 1 review

Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome 2022 · Cochrane Headline outcomes only
OR 0.94 [0.66, 1.32]
15 studies · 736 participants
High