Findings

What do systematic reviews say?

12 questions · 12 findings · 7 reviews

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No studies found 2 · 16.7%GRADE not reported 0 · 0%Very low 7 · 58.3%Low 2 · 16.7%Moderate 1 · 8.3%High 0 · 0%

RhCG vs uhCG

Miscarriage · patients with final oocyte maturation triggering in IVF and ICSI cycles

RhCG showed no clear difference in miscarriage rate per woman compared with uhCG (low certainty).

1 finding from 1 review

Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles 2016 · Cochrane Headline outcomes only
OR 0.72 [0.41, 1.25]
9 studies · 1347 participants
Low

hCG vs GnRH agonist

Miscarriage · women trying to conceive by intrauterine insemination

It is very uncertain whether hCG changes miscarriage rate per pregnancy compared with gnRH‐a (very low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.72 [0.48, 6.2]
4 studies · 74 participants
Very low

u‐hCG vs r‐hCG

Miscarriage · women trying to conceive by intrauterine insemination

It is very uncertain whether u‐hCG changes miscarriage rate per pregnancy compared with r‐hCG (very low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 0.57 [0.13, 2.47]
2 studies · 109 participants
Very low

Early hCG vs late hCG

Miscarriage · women trying to conceive by intrauterine insemination

It is very uncertain whether early hCG changes miscarriage rate compared with late hCG (very low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 0.51 [0.08, 3.28]
1 study · 65 participants
Very low

Low‐dose hCG vs FSH throughout the COH

Miscarriage · women undergoing assisted reproduction

It is very uncertain whether low‐dose hCG changes miscarriage compared with FSH throughout the COH (very low certainty).

1 finding from 1 review

FSH replaced by low‐dose hCG in the late follicular phase versus continued FSH for assisted reproductive techniques 2013 · Cochrane Headline outcomes only
RR 1.08 [0.5, 2.31]
4 studies · 127 participants
Very low

Modified natural cycle FET (HCG trigger) vs HT FET

Miscarriage · subfertile women

The review found no eligible studies for this question.

1 finding from 1 review

Cycle regimens for frozen‐thawed embryo transfer 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Modified natural cycle FET (HCG trigger) vs HT + GnRHa FET

Miscarriage · subfertile women

Modified natural cycle FET (HCG trigger) showed no clear difference in miscarriage rate per woman compared with HT + GnRHa suppression FET (low certainty).

1 finding from 1 review

Cycle regimens for frozen‐thawed embryo transfer 2017 · Cochrane Headline outcomes only
OR 0.74 [0.25, 2.19]
1 study · 236 participants
Low

GnRH agonists vs HCG

Miscarriage · subfertile women

GnRH agonist probably leads to higher miscarriage compared with HCG (moderate certainty).

1 finding from 1 review

Gonadotropin‐releasing hormone agonist versus HCG for oocyte triggering in antagonist‐assisted reproductive technology 2014 · Cochrane Headline outcomes only
OR 1.74 [1.1, 2.75]
11 studies · 1198 participants
Moderate

Coasting vs follicle stimulating hormone administration at time of hCG

Miscarriage · women undergoing assisted reproduction

The review found no eligible studies for this question.

1 finding from 1 review

Coasting (withholding gonadotrophins) for preventing ovarian hyperstimulation syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Miscarriage · subfertile women undergoing assisted reproduction

It is very uncertain whether the intervention changes miscarriage (very low certainty).

1 finding from 1 review

Intrauterine administration of human chorionic gonadotropin (hCG) for subfertile women undergoing assisted reproduction 2018 · Cochrane Headline outcomes only
RR 1.04 [0.81, 1.35]
11 studies · 3927 participants
Very low

Natural cycle FET vs modified natural cycle FET (HCG trigger)

Miscarriage · subfertile women

It is very uncertain whether natural cycle FET changes miscarriage rate per woman compared with modified natural cycle FET (HCG trigger) (very low certainty).

1 finding from 1 review

Cycle regimens for frozen‐thawed embryo transfer 2017 · Cochrane Headline outcomes only
OR 0.2 [0.01, 4.13]
1 study · 168 participants
Very low

RhLH vs uhCG

Miscarriage · patients with final oocyte maturation triggering in IVF and ICSI cycles

It is very uncertain whether rhLH changes miscarriage rate per woman compared with uhCG (very low certainty).

1 finding from 1 review

Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles 2016 · Cochrane Headline outcomes only
OR 0.95 [0.38, 2.4]
2 studies · 280 participants
Very low