Findings

What do systematic reviews say?

72 questions · 72 findings · 12 reviews

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No studies found 9 · 12.5%GRADE not reported 1 · 1.4%Very low 27 · 37.5%Low 23 · 31.9%Moderate 12 · 16.7%High 0 · 0%

RhCG vs uhCG

Ongoing pregnancy / live birth rate per woman · patients with final oocyte maturation triggering in IVF and ICSI cycles

RhCG showed no clear difference in ongoing pregnancy/live birth rate per woman compared with uhCG (moderate certainty).

1 finding from 1 review

Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles 2016 · Cochrane Headline outcomes only
OR 1.15 [0.89, 1.49]
7 studies · 1136 participants
Moderate

RhCG vs uhCG

Moderate or severe OHSS · patients with final oocyte maturation triggering in IVF and ICSI cycles

RhCG showed no clear difference in OHSS per woman ‐ moderate to severe OHSS compared with uhCG (low certainty).

1 finding from 1 review

Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles 2016 · Cochrane Headline outcomes only
OR 1.76 [0.37, 8.45]
3 studies · 417 participants
Low

RhCG vs uhCG

Clinical pregnancy rate · patients with final oocyte maturation triggering in IVF and ICSI cycles

RhCG showed no clear difference in clinical pregnancy rate per woman compared with uhCG (moderate certainty).

1 finding from 1 review

Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles 2016 · Cochrane Headline outcomes only
OR 1.06 [0.87, 1.29]
13 studies · 1806 participants
Moderate

RhCG vs uhCG

Miscarriage · patients with final oocyte maturation triggering in IVF and ICSI cycles

RhCG showed no clear difference in miscarriage rate per woman compared with uhCG (low certainty).

1 finding from 1 review

Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles 2016 · Cochrane Headline outcomes only
OR 0.72 [0.41, 1.25]
9 studies · 1347 participants
Low

RhCG vs uhCG

Adverse events per woman · patients with final oocyte maturation triggering in IVF and ICSI cycles

RhCG probably leads to lower adverse events per woman compared with uhCG (moderate certainty).

1 finding from 1 review

Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles 2016 · Cochrane Headline outcomes only
OR 0.52 [0.35, 0.76]
5 studies · 561 participants
Moderate

hCG vs placebo/no treatment

Live birth or ongoing pregnancy · subfertile women

It is very uncertain whether hCG changes live birth or ongoing pregnancy compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Luteal phase support for assisted reproduction cycles 2015 · Cochrane Headline outcomes only
OR 1.76 [1.08, 2.86]
3 studies · 527 participants
Very low

hCG vs placebo/no treatment

Clinical pregnancy · subfertile women

It is very uncertain whether hCG changes clinical pregnancy compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Luteal phase support for assisted reproduction cycles 2015 · Cochrane Headline outcomes only
OR 1.3 [0.9, 1.88]
5 studies · 746 participants
Very low

hCG vs placebo/no treatment

OHSS · subfertile women

hCG may leads to higher OHSS compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for assisted reproduction cycles 2015 · Cochrane Headline outcomes only
OR 4.28 [1.91, 9.6]
1 study · 387 participants
Low

hCG vs LH surge

Live birth rate per couple · women trying to conceive by intrauterine insemination

It is very uncertain whether hCG changes live birth rate per couple compared with LH surge (very low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1 [0.06, 18.08]
1 study · 24 participants
Very low

hCG vs GnRH agonist

Live birth rate per couple · women trying to conceive by intrauterine insemination

hCG showed no clear difference in live birth rate per couple compared with gnRH‐a (low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.04 [0.42, 2.56]
3 studies · 104 participants
Low

hCG vs GnRH agonist

Pregnancy rate · women trying to conceive by intrauterine insemination

hCG showed no clear difference in pregnancy rate per couple compared with gnRH‐a (low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.14 [0.63, 2.08]
4 studies · 206 participants
Low

hCG vs GnRH agonist

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

It is very uncertain whether hCG changes multiple pregnancy rate per pregnancy compared with gnRH‐a (very low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 0.15 [0.02, 1.38]
4 studies · 74 participants
Very low

hCG vs GnRH agonist

Miscarriage · women trying to conceive by intrauterine insemination

It is very uncertain whether hCG changes miscarriage rate per pregnancy compared with gnRH‐a (very low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.72 [0.48, 6.2]
4 studies · 74 participants
Very low

hCG vs LH surge

Pregnancy rate · women trying to conceive by intrauterine insemination

hCG showed no clear difference in pregnancy rate per couple compared with LH surge (low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.33 [0.72, 2.45]
4 studies · 275 participants
Low

hCG vs GnRH agonist

OHSS · women trying to conceive by intrauterine insemination

hCG showed no clear difference in OHSS per cycle compared with gnRH‐a (low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 2.27 [0.65, 7.91]
3 studies · 456 participants
Low

hCG vs LH surge

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

It is very uncertain whether hCG changes multiple pregnancy rate per pregnancy compared with LH surge (very low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.12 [0.17, 7.6]
2 studies · 42 participants
Very low

u‐hCG vs r‐hCG

Live birth rate per couple · women trying to conceive by intrauterine insemination

u‐hCG showed no clear difference in live birth rate per couple compared with r‐hCG (low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.17 [0.68, 2.03]
1 study · 284 participants
Low

u‐hCG vs r‐hCG

Pregnancy rate · women trying to conceive by intrauterine insemination

u‐hCG showed no clear difference in pregnancy rate per couple compared with r‐hCG (low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 1.02 [0.65, 1.57]
2 studies · 409 participants
Low

u‐hCG vs r‐hCG

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

u‐hCG showed no clear difference in multiple pregnancy rate per pregnancy compared with r‐hCG (low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 0.99 [0.4, 2.47]
2 studies · 109 participants
Low

u‐hCG vs r‐hCG

Miscarriage · women trying to conceive by intrauterine insemination

It is very uncertain whether u‐hCG changes miscarriage rate per pregnancy compared with r‐hCG (very low certainty).

1 finding from 1 review

Synchronised approach for intrauterine insemination in subfertile couples 2014 · Cochrane Headline outcomes only
OR 0.57 [0.13, 2.47]
2 studies · 109 participants
Very low